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Sleep Apnea's hidden danger: low oxygen may fuel diabetes risk

NCT ID NCT03695315

Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how low oxygen levels (hypoxia) in people with obstructive sleep apnea affect the body's ability to use insulin. Researchers measured insulin resistance in the liver and fat tissue of 48 non-diabetic adults. The goal was to understand why some sleep apnea patients are more likely to develop diabetes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

48 people

The number who actually took part.

Started

Oct 2018

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be recruited from the UCSF Clinical Sleep Medicine Laboratory. Patients seen by UCSF sleep medicine physicians (including Dr. Krystal \[Lab Co-Director\]) in sleep clinic and those who are referred for polysomnography (PSG) for OSA and for whom the physician has provided approval to be approached, will be contacted by the study coordinator and offered the opportunity to be screened to participate in the study. The study coordinator will review the consent form with the prospective volunteers and will ask for their approval to have their PSG data reviewed by Dr. Krystal, who will determine if the participants meet PSG entry criteria for participation in the study and if found to qualify, to be contacted by phone.

Ages

19 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Sixty nondiabetic men and women Inclusion Criteria: * Age \>19 years * BMI \>18.5 kg/m2 * Participants newly diagnosed obstructive sleep apnea (OSA) must meet the criteria for one of the two following groups: * OSA with hypoxia (H-OSA) defined as those with an H-Apnea Hypopnea Index (AHI) ≥15 so as to match the NH-OSA subjects in event frequency and because this is the range defined as more than mild OSA such that we would be likely to see pathology associated with OSA; or, * OSA without hypoxia (NH-OSA) defined as having a rate of non-hypoxic respiratory events ≥ 15 per hour (NH-AHI≥15) and having a rate of hypoxic events of less than 5 per hour (H-AHI\<5,(52)). Exclusion Criteria: * Type 1 or 2 diabetes mellitus currently being treated with medications * History of chronic obstructive pulmonary disease (COPD) or parenchymal lung disease * Unstable hypertension * Treatment for asthma (dependent on type of treatment) * Current alcohol consumption exceeding 1 drink/day in women and 2 in men * HIV infection * Infectious hepatitis * Pregnancy or lactation within the past six months * Irregular use of any hypolipidemic agent * History of surgery for obesity * Hgb below the lower limit of normal * Aspartate transaminase (AST) or alanine transaminase (ALT) greater than 3 times the upper limit of normal * Change in body weight \>5% within preceding 3 months (by self-report)

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Conditions

The condition(s) this trial relates to.

Hypoxia Insulin Resistance obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypoxia Insulin resistance Obstructive sleep apnea

Contacts and locations

Locations

  • University of California San Francisco

    San Francisco, California, 94110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.