New skin booster from human tissue shows promise in wrinkle fight
NCT ID NCT07155278
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This completed Phase 4 trial tested whether a skin booster made from human tissue (phADM) plus hyaluronic acid works better than hyaluronic acid alone for wrinkles and skin texture. Twenty adults received three injections on one cheek with the combination and on the other cheek with HA alone. Researchers measured wrinkle depth, skin density, volume, and lifting over 20 weeks to see which side improved more.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- particulated human acellular dermal matrix (phADM) combined with hyaluronic acid
- What this could lead to
- If it works, this could offer a more effective option for reducing wrinkles and improving skin firmness and texture.
- What could go wrong
- This is a small, early-phase trial with only 20 participants, so results may not apply to everyone. The improvement over existing treatments may be modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
20 people
The number who actually took part.
- Started
-
Nov 2024
- Finished
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May 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 to 65 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female aged 30 to 65 years old * Those with an Allergan Cheek Smoothness Scale (ACSS) score of 2-3 during screening Exclusion Criteria: * Those who have received dermal fillers, botulinum toxin injections, mesotherapy, or other cosmetic procedures (e.g., laser) on the face within 12 months of screening or plan to receive such treatments during the trial period. * Those who received facial wrinkle correction treatment within 6 months of screening * Those with inflammatory diseases in the facial area * Those with infectious diseases, skin grafts, keloids, or hypertrophic scars on the face. * Those with autoimmune diseases * Those who have experienced anaphylaxis or severe complex allergies for any reason * Those who were prescribed anticoagulant therapy within 2 weeks of the screening date * Those with a history of serious cardiopulmonary disease * Breastfeeding * Those who have started using or taking external or oral agents for wrinkle improvement within 30 days of screening
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Severance Hospital, Yonsei University College of Medicine
Seoul, 03722, South Korea
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