Blood concentrate may boost bone growth for dental implants
NCT ID NCT03495700
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a special blood concentrate (L-PRF) mixed with bone substitute helps grow more bone in the sinus area for people needing dental implants. Twenty-three adults with jawbone loss received either the L-PRF block or a standard bovine bone graft. After six months, the amount of new bone was measured using 3D scans, and implants were followed for up to five years.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- L-PRF block (a mix of patient's own blood concentrate and bone substitute) and DBBM (bovine bone graft)
- What this could lead to
- If L-PRF works better, it could improve bone growth for dental implants, reducing the need for repeat procedures.
- What could go wrong
- This is a small, early study with only 23 participants, so results may not apply to everyone. The procedure also carries typical surgical risks like infection or graft failure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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23 people
The number who actually took part.
- Started
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Mar 2018
- Finished
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Jun 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Males and females ≥ 18 years of age. * Ability to understand the nature of the proposed surgical procedure and sign an informed consent form. * ASA I and ASA II. * In need of an implant in the posterior region of the maxilla, * RBH of \<4 mm or RBH \>4 mm but no transcrestal approach possible (due to anatomy). * Healthy oral mucosa and no active periodontal disease. * Edentulous sites consisting of native, non-augmented bone. Exclusion Criteria: * General contraindications for implant placement and/or surgical treatment. * Acute infection or residual lesions in the edentulous sites. * Acute maxillary sinus pathosis. * Ongoing inflammatory and/or autoimmune diseases of the oral cavity. * Patients with poor oral hygiene who are not amenable to improvement. * Immunosuppressants, corticosteroids, or bisphosphonate * History of malignancy, radiotherapy, or chemotherapy for malignancy within the past five years. * Smoker \> 10 cigarettes. * Uncontrolled insulin-dependent diabetes. * Pregnant or lactating women. * Alcohol and drug abuse.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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UZ Leuven
Leuven, 3000, Belgium
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Other studies related to the condition(s) this trial covers.