One shot to stop cancer: HPV vaccine study could change global prevention

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * INCLUSION CRITERIA AT ENROLLMENT: Female. * INCLUSION CRITERIA AT ENROLLMENT: Aged between 18 and 30 years inclusive. * INCLUSION CRITERIA AT ENROLLMENT: Living in the study area. * INCLUSION CRITERIA AT ENROLLMENT: Able to communicate with study personnel. * INCLUSION CRITERIA AT ENROLLMENT: Willing to participate in the study and sign the informed consent. * INCLUSION CRITERIA AT ENROLLMENT: In good health as determined by a medical history (physical exam will be conducted if necessary per the doctor's criterion). * DEFERRAL CRITERIA AT ENROLLMENT VISIT: The enrollment visit will be deferred (i.e., rescheduled for another date) for participants if: the self-collected cervical sample is not able to be collected. * DEFERRAL CRITERIA AT THE VACCINATION VISIT: The vaccination visit will be deferred (i.e., rescheduled for another date) for participants if: * They have an acute disease that precludes vaccination (though vaccines can be administered to potential participants with a minor illness such as diarrhea and mild upper respiratory infection) * They are receiving immunosuppressive treatment, e.g. corticosteroids * They have received any registered vaccine in the last 15 days. Exclusion Criteria: * EXCLUSION CRITERIA AT ENROLLMENT VISIT: They have been vaccinated against human papillomavirus (HPV). * EXCLUSION CRITERIA AT ENROLLMENT VISIT: They are allergic to yeast or another vaccine components. * EXCLUSION CRITERIA AT ENROLLMENT VISIT: They have a diagnosis of an autoimmune, degenerative, or neurological disease without treatment or adequate control; a progressive or severe neurological disease; a genetic immunodeficiency; or any other serious chronic disease without treatment and / or adequate control that, according to the principal investigator or designee, for which vaccination is contraindicated. * EXCLUSION CRITERIA AT ENROLLMENT VISIT: They have plans to move outside the country in the next six months. * EXCLUSION CRITERIA AT ENROLLMENT VISIT: They refuse or are unable to self-collect the cervical sample. * EXCLUSION CRITERIA AT ENROLLMENT VISIT: They are pregnant. * EXCLUSION CRITERIA AT ENROLLMENT VISIT: They do not have an identification document. * EXCLUSION CRITERIA AT ENROLLMENT VISIT: The clinician determining eligibility in agreement with the principal investigator considers that there is a reason that precludes participation. * EXCLUSION CRITERIA AT VACCINATION VISIT: Between the enrollment and vaccine visit, they have been vaccinated against HPV. * EXCLUSION CRITERIA AT VACCINATION VISIT: Between the enrollment and vaccine visit, they are being evaluated for or have received a diagnosis of: an autoimmune, degenerative, or neurological disease without treatment or adequate control; a progressive or severe neurological disease; a genetic immunodeficiency; or any other serious chronic disease without treatment and/or adequate control, for which vaccination is contraindicated according to the principal investigator or designee. * EXCLUSION CRITERIA AT VACCINATION VISIT: They have plans to move outside the country in the next six months. * EXCLUSION CRITERIA AT VACCINATION VISIT: They refuse the urine pregnancy test. * EXCLUSION CRITERIA AT VACCINATION VISIT: They have a positive urine pregnancy test result. * EXCLUSION CRITERIA AT VACCINATION VISIT: They are pregnant. * EXCLUSION CRITERIA AT VACCINATION VISIT: They refuse or are unable to perform the self-collected cervical sample. * EXCLUSION CRITERIA AT VACCINATION VISIT: The clinician determining eligibility in agreement with the principal investigator considers that there is a reason that precludes participation.