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One pill before skin surgery may stop infections, study says

NCT ID NCT04580472

Prevention Sponsor: Carilion Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a single dose of oral antibiotic (cephalexin or clindamycin) given before certain skin surgeries can prevent surgical site infections. About 574 adults having skin flaps, grafts, or lower-leg procedures will be randomly assigned to receive either the antibiotic or a placebo. Researchers will track infections for 30 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cephalexin or Clindamycin hydrochloride (single oral dose)
What this could lead to
If it works, this could show that a single antibiotic dose before certain skin surgeries prevents infections, potentially reducing the need for longer antibiotic courses.
What could go wrong
This is a single-center trial, so results may not apply everywhere. The infection rate in skin surgery is already low, so the benefit may be small or not statistically significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

574 people

The number who actually took part.

Started

Oct 2020

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years of age or older * presenting to Carilion Clinic Dermatology and Mohs surgery in Roanoke, VA at Riverside 1 * suspected to undergo a single-staged repair including a skin flap or graft on the nose * OR suspected to undergo single-staged repair including a skin graft or flap or wedge resection 1 on the ear * OR undergoing Mohs with closure or partial closure or surgical excision on the lower extremity below the knee Exclusion Criteria: * patients with intellectual or mental impairment affecting ability to give informed consent * use of any antibiotic (other than intervention) within 48 hours of the surgery suspected infection at time of surgery * inability to take cephalexin or clindamycin hydrochloride due to allergy or intolerance current inflammatory skin disease affecting the surgical site * Patients undergoing concurrent surgery to oral or nasal mucosa * Patients who have had a recent prosthetic joint surgery within two years and have been told they require antibiotic prophylaxis. * Patients who are currently pregnant, concerned they could be pregnant, actively trying to conceive, or missed last menstrual period that is not explainable by a birth control method.

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Conditions

The condition(s) this trial relates to.

Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Surgical site infection

Contacts and locations

Locations

  • Carilion Clinic

    Roanoke, Virginia, 24016, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.