Could a simple Anti-Gas drug make colonoscopies more effective?
NCT ID NCT07674160
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This study investigates whether adding simethicone, an anti-foaming agent, to standard bowel preparation improves colon cleanliness during water-exchange colonoscopy. About 180 adults undergoing screening or diagnostic colonoscopy will be randomly assigned to receive either simethicone plus polyethylene glycol (PEG) or PEG alone. The goal is to see if simethicone reduces bubbles and improves visibility, potentially leading to better detection of polyps and adenomas.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- simethicone
- What this could lead to
- If effective, adding simethicone could offer a simple, low-cost way to improve colonoscopy quality and polyp detection.
- What could go wrong
- This is a small, single-center study. The benefit may be modest or not apply to other colonoscopy techniques.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 180 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Consecutive patients undergoing screening, surveillance, or diagnostic colonoscopy. * Procedures performed by participating endoscopists. * Ability to provide written informed consent. Exclusion Criteria: * Colonoscopy performed using air insufflation or water immersion technique. * History of colorectal surgery (e.g., colectomy or colostomy). * Known or suspected colonic obstruction or severe stricture. * Requirement for inpatient bowel preparation. * Known allergy or hypersensitivity to simethicone. * Unable or unwilling to provide informed consent.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.