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Silent gut narrowings in Crohn's: to treat or not to treat?

NCT ID NCT07167745

Knowledge-focused Sponsor: University Medical Center Zvezdara Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at 150 adults with Crohn's disease who had narrowings in the small intestine (strictures) but no symptoms. Researchers reviewed medical records to see how often these silent strictures later caused problems like belly pain, nausea, or vomiting. The goal is to help doctors decide whether to monitor or treat such strictures early.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors know when it's safe to just watch silent strictures in Crohn's disease and when to treat them, leading to better care guidelines.
What could go wrong
This is an observational study reviewing past medical records, so it can't prove cause and effect. Results may not apply to all patients, and the findings are only as reliable as the records reviewed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

150 people

The number who actually took part.

Started

Jun 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This retrospective multicenter study will include patients aged above 18 years diagnosed with asymptomatic small bowel strictures between 2015 and 2023, with a minimum follow-up of one year, selected based on predefined inclusion and exclusion criteria.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Patients who are asymptomatic, with no clinical signs of intestinal symptomatology (absence of abdominal pain, distension, nausea, vomiting, weight loss, diahorrea). * Patients 18 years and older * Small bowel stricture diagnosed incidentally either: 1. at the time of initial Crohn's disease (CD) diagnosis (baseline visit), or 2. in patients with a previously established diagnosis of mild CD who have maintained stable clinical, endoscopic and radiographic remission without previous stenosis for a minimum of 2 years prior to study entry. * Diagnosis of Crohn's disease confirmed according to accepted clinical, endoscopic, radiologic, and/or histologic standards. * Evidence of small bowel involvement by CD, either in the form of ileal, ileocolonic or jejunal disease. Presence of a small bowel stricture confirmed by MR enterography, intestinal ultrasound (IUS), or endoscopy. * Only patients who have at least one year of longitudinal follow-up data in the medical record after the baseline/index evaluation will be included. * Patients who went to colonoscopy due to asymptomatic iron deficiency anemia and/or positive fecal occult blood test or for routine CD follow up * Minimum follow up period is one year, or event happened whichever comes first Exclusion Criteria: * Presence of symptomatic strictures at the time of stenosis detection. * Incomplete clinical data or follow-up * Strictures attributable to neoplastic processes, prior radiation therapy, or congenital anomalies. * Strictures are located exclusively in the colon. * Clinical symptoms of active CD at the time the stricture was identified. * History of prior small bowel or colonic resection.

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Conditions

The condition(s) this trial relates to.

Crohn disease inflammatory bowel disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inflammatory bowel disease

Contacts and locations

Locations

  • University Hospital Zvezdara

    Belgrade, Serbia, 11000, Serbia

More trials for these conditions

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