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Scientists probe hidden triggers of sickle cell pain crises

NCT ID NCT05646888

Knowledge-focused Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how platelets and inflammation work together during painful crises in adults with sickle cell disease. Researchers will take blood samples from 25 patients hospitalized for a crisis to analyze these processes. The goal is to better understand the disease, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could reveal new targets for treatments that reduce painful crises in sickle cell disease.
What could go wrong
This is a small, early observational study (25 participants) that only collects blood samples. It is not testing a treatment, so it may not lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2023

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with sickle cell disease diagnosis

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient with sickle cell disease diagnosis, hospitalized in emergency department and/or internal medicine department * Patient older than 18 years * Written consent to participate to the study * Patient with health insurance * Patient able to receive information about the study Exclusion Criteria: * Age \< 18 years * Non consent to participate to the study * Women in pregnancy or breastfeeding * Treatment with aspirin or non steroidal anti inflammatory drug * Protected patient * Patient already involved in a study requiring collection of additional biological samples

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Conditions

The condition(s) this trial relates to.

sickle cell disease Thromboinflammation Vaso-Occlusive Crises

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Platelet activation Sickle cell disease Thromboinflammation

Contacts and locations

Locations

  • IUCT-Oncopole University Hospital

    Toulouse, 31500, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.