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Can a shorter surgical tunnel fix swallowing without causing heartburn?

NCT ID NCT07325071

Symptom relief Sponsor: Asian Institute of Gastroenterology, India Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compares two ways of doing a surgery called POEM for people with type II achalasia, a condition where the esophagus has trouble moving food into the stomach. The standard method uses a long tunnel under the lining of the esophagus, but this can cause bad acid reflux afterward. The new method uses a shorter tunnel and focuses the cut only at the tight muscle. The trial will enroll 636 adults and track how well each method relieves symptoms and how often it causes reflux.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Procedure: Peroral Endoscopic Myotomy (POEM) with short submucosal tunnel
What this could lead to
If successful, this could offer a safer surgical option for achalasia patients with less post-surgery acid reflux and faster recovery.
What could go wrong
This is an early-stage trial with no results yet. The shorter tunnel might not relieve swallowing symptoms as well as the standard approach.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 636 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults aged \>18 years. 2. Diagnosis of Type II achalasia naïve patients based on high-resolution manometry (Chicago Classification v4). 3. Eckardt score \>3. 4. Written informed consent Exclusion Criteria: 1. Type I or III achalasia. 2. Previous endoscopic or surgical treatment for achalasia. 3. Contraindications for POEM (e.g., coagulopathy, portal hypertension). 4. Sigmoid Achalasia

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Conditions

The condition(s) this trial relates to.

esophageal disorder idiopathic achalasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Esophageal diseases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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Other studies related to the condition(s) this trial covers.