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Could preterm babies safely get less antibiotics?

NCT ID NCT07610486

First seen May 28, 2026 · Last updated Jun 20, 2026 · Updated 5 times

Summary

This study looks at whether preterm infants in the NICU can safely stop taking the antibiotic ampicillin after 24 to 36 hours instead of the usual 48 hours. Researchers will measure drug levels in the blood and monitor the babies for 30 days. The goal is to see if a shorter course still provides enough protection against early onset sepsis while reducing unnecessary medication.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Duke Health Neonatal Intensive Care Unit

    Durham, North Carolina, 27705, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ampicillin

What this could lead to

If successful, this could show that shorter antibiotic courses are safe and effective for preterm infants, reducing unnecessary drug exposure.

What could go wrong

This is an early-phase trial with only 60 infants, so results may not apply broadly. There is a risk that shorter treatment fails to prevent infection.

Conditions

The condition(s) this trial relates to.

neonatal sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.