Breathing training may shield seniors from disease
NCT ID NCT07018895
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a personalized breathing training that alternates low and high oxygen levels in 20 healthy adults aged 60-74. The goal was to see if it is safe and could create an 'organ-protective' state. The training was tailored using a brain oxygen monitor. This is a very early safety study, so it does not yet show if this approach actually prevents disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Intermittent hypoxic-hyperoxic breathing training (alternating low and high oxygen air)
- What this could lead to
- If this approach proves safe and effective in larger trials, it could point toward a non-drug way to help older adults become more resilient to stress and disease.
- What could go wrong
- This is a very small, early study with only 20 healthy volunteers. It only looked at safety and basic body responses, not whether it actually prevents disease or extends life.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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20 people
The number who actually took part.
- Started
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Jul 2025
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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60 to 74 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 60-74 years. 2. Signed informed consent. Non-inclusion criteria 1. Charlson Comorbidity Index ≤ 3 (with a score of 1 or more on all criteria except for the age factor). 2. Conditions associated with chronic hypoxia or hyperoxia. 3. Uncompensated coronary artery disease. 4. Chronic diseases in the acute or decompensated phase. Exclusion Criteria: 1. Withdrawal from further participation in the study (revocation of informed consent), unrelated to any of the subsequent points. 2. Inability to reduce cerebral tissue saturation by 20% from baseline during the hypoxic test. 3. Individual intolerance to IHHT sessions. 4. Development of one of the following complications during IHHT sessions: 1). Disorder of consciousness. 2). The state of syncope. 3). Development of any other life-threatening condition. The fact and the reason for the Subject to be excluded from the study will be recorded in the CRF (Case Report Form), along with all data collected during the study, for further analysis, if planned. If exclusion occurs according to points 1 and 2 of the exclusion criteria, the subject will be replaced with another participant. If exclusion occurs according to any of the subsequent points, replacement will not be performed. If exclusion occurs according to points 3 and 4, patients will be thoroughly examined and remain under the observation of the study physicians until their condition is stabilized
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia
Tomsk, 634012, Russia