New hope for kids with brittle bones: trial tests drug to reduce fractures
NCT ID NCT05768854
Summary
This study is testing whether a new drug called setrusumab works better than the current standard treatment (bisphosphonates) at reducing broken bones in children with osteogenesis imperfecta, a genetic condition that causes fragile bones. Children aged 2 to 7 with a history of fractures will receive either the new drug or the standard treatment for two years, then all will switch to the new drug. The main goal is to see which treatment leads to fewer fractures.
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Contacts and locations
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Locations
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Azienda Ospedaliera Universitaria Policlinico Umberto I
Roma, 00161, Italy
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital at London Health Sciences Centre
London, Ontario, N6A 5W9, Canada
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Children's National Hospital DC
Washington D.C., District of Columbia, 20010, United States
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Childrens Hospital LA
Los Angeles, California, 90027, United States
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Childrens Hospital Of Eastern Ontario Research Institute, University Of Ottawa
Ottawa, KIH 8L1, Canada
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Hospital de Clinicas de Porto Alegre (HCPA)
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Institut Imagine
Paris, 75015, France
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Nemours/ Alfred i. duPoint Hospital for Children
Wilmington, Delaware, 19803, United States
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Phoenix Children's Hospital
Phoenix, Arizona, 85206, United States
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Shriners Hospitals for Children Chicago
Chicago, Illinois, 60707, United States
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Universitair Medisch Centrum Utrecht (UMCU) - Wilhelmina Kinderziekenhuis
Utrecht, 3584 EA, Netherlands
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University of North Carolina at Chapel Hill (UNC)
Chapel Hill, North Carolina, 27599, United States
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University of South Florida
Tampa, Florida, 33612, United States
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Uniwersytet Medyczny w Lodzi - Klinika Endokrynologii i Chorob Metabolicznych
Lodz, 91-738, Poland
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Vanderbilt University Medical Center (VUMC)
Nashville, Tennessee, 37212, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Yale New Haven Hospital
New Haven, Connecticut, 06510, United States
Conditions
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