Sepsis study aims to sharpen diagnosis in thailand
NCT ID NCT03379402
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study in Thailand looked at how well the latest sepsis definition (Sepsis-3) works for patients with community-acquired sepsis. Researchers collected blood and other samples from 1002 adults at a hospital in Ubon Ratchathani. They tracked who survived for 28 days and what germs caused the infections. The goal is to better understand sepsis in this region and improve care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could improve how doctors diagnose and treat sepsis in community settings, potentially reducing deaths.
- What could go wrong
- This is an observational study, not a treatment trial. It cannot prove that any intervention works, and results may not apply outside Thailand.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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1,002 people
The number who actually took part.
- Started
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Feb 2018
- Finished
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Mar 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult patients, both males and females, presenting with sepsis will be approached for participation in the study.
- Ages
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18 years and older
- Sex
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Anyone
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Males and females 18 years old. 2. Thai nationality. 3. Required hospitalization as decided by the attending physician 4. Documented by attending physician that an infection is the primary cause of illness leading to the hospitalization. These can be infections due to any pathogens (bacteria, viruses, fungi and parasites). 5. qSOFA (quick Sepsis-related Organ Failure Assessment) score ≥ 2 defined as 2 or more of the following: * Respiratory rate ≥22 /min or required ventilator * Alteration of mental status (GCS\<15 or 10T with endotracheal tube) * Systolic blood pressure ≤100 mm Hg Exclusion Criteria: 1. Infection is not suspected to be a primary cause of the current illness episode leading to the hospitalization. For example, community-acquired sepsis is considered to be due to stroke, cardiovascular diseases, acute myocardial infarction, cancer, burn, injury, and trauma. 2. Hospitalized at the study site for this current episode for more than 24 hours before enrollment. 3. Hospitalized for this current episode for more than 72 hours at another primary/referring hospital 4. Prior to this current episode, the patient was admitted to any hospital within the last 30 days. 5. Prior to enrolment, it is documented by the attending physician that hospital acquired infection is associated with the cause of sepsis. Please note that the following conditions are not exclusion criteria, and patients with the following conditions can be enrolled into the study. * Confirmed diagnosis by any method of an infection as a major cause of illnesses leading to hospitalization. For example, a patient who already has had a definite diagnosis of malarial infection by blood smear. * Clinical diagnosis of any specific disease or any specific syndromes such as acute infective diarrhea, acute pneumonia, acute encephalomyelitis and acute myocarditis. * Suspected of having both infectious and non-infectious diseases and infectious disease is a primary cause of illnesses (primary diagnosis) leading to the hospitalization. For example, acute pneumonia with stroke as an underlying disease, etc. * Patients who are admitted to other hospitals and referred to the study site. For example a referred patient who admit to the first hospital less than 24 hours prior to enrollment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Sappasithiprasong Hospital
Ubon Ratchathani, 34000, Thailand
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Other studies related to the condition(s) this trial covers.
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