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Can seed cycling capsules ease PMS symptoms naturally?

NCT ID NCT07655466

Symptom relief Sponsor: Superlune Inc. d/b/a Two Moons Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether daily seed cycling capsules can reduce common PMS symptoms like cramps, bloating, fatigue, and mood swings. Forty women aged 18 to 45 with a history of menstrual symptoms will take the capsules for two menstrual cycles and report changes through questionnaires. The study aims to see if this dietary supplement approach improves overall menstrual experience.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Seed cycling capsules (Zest and Zen formulations)
What this could lead to
If effective, seed cycling could offer a natural, non-hormonal option for managing PMS symptoms and improving menstrual health.
What could go wrong
This is a small, early-stage trial with no placebo group, so results may not prove the capsules work better than no treatment. Individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jul 2025

Finished

Sep 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Be female. * Be 18-45 years of age. * Have experienced at least five of the following symptoms during the last three menstrual cycles: Heavy flow Prolonged, shortened, or irregular periods Headaches or migraines Low mood Fatigue Bloating Premenstrual or menstrual cramps Breast tenderness Poor sleep Constipation or diarrhea Weight gain or fluctuations Irritability or anger Sick days or reduced social activity due to menstrual symptoms Hormonal acne * Be generally healthy. * Have a menstrual cycle length between 23 and 35 days. * Track menstrual cycles and be able to predict period dates. * Be willing to refrain from taking products, medications, or supplements targeting menstrual health during the study. Exclusion Criteria: * Use of hormonal contraception. * Allergy to sesame. * Chronic conditions that would interfere with study participation, including oncological and psychiatric disorders. * Pregnant, breastfeeding, or trying to conceive. * Unwillingness to follow the protocol. * Menopause or menopausal symptoms. * Recent or planned invasive medical procedures. * History of substance abuse. * Diabetes or other endocrine-related conditions. * Current or planned participation in another research study. * Use of hormone-modulating medications or therapies. * Planned insertion or replacement of an IUD within 12 weeks. * Diagnosis of endometriosis, polycystic ovary syndrome (PCOS), or adenomyosis.

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Conditions

The condition(s) this trial relates to.

premenstrual tension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Menstrual symptoms Premenstrual syndrome

Contacts and locations

Locations

  • Citruslabs

    Las Vegas, Nevada, 89118, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.