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Could a simple drug order change emergency intubation success?

NCT ID NCT07741578

Disease control Sponsor: Zhongnan Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial asks whether giving a muscle relaxant before a sedative, rather than the usual reverse order, improves the success of emergency intubation. It will involve 380 adults in the emergency department who need rapid sequence intubation. Researchers will compare first-pass success rates, time to intubation, oxygen levels, and risk of post-traumatic stress disorder between the two drug sequences.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
The order of two emergency drugs: a sedative (propofol) and a muscle relaxant (rocuronium), given during rapid sequence intubation.
What this could lead to
If one order works better, it could make emergency intubation safer and more successful, reducing complications like low oxygen levels and distress.
What could go wrong
This is a single-center trial, and results may not apply to all emergency settings. The order of drugs may not significantly change outcomes, and both drugs carry risks like low blood pressure or breathing problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

380 people

The number who actually took part.

Started

Jul 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * in ED/EICU required emergency intubation * RSI required Exclusion Criteria: * Pregnancy * do not intubation orders * Declined participation * Other trials * Non-emergent cases * Active CPR

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rapid sequence induction and intubation Tracheal intubation

Contacts and locations

Locations

  • Zhongnan Hospital of Wuhan University

    Wuhan, China

More trials for these conditions

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