Promising drug trial for thyroid eye disease halted early

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: * Patient had to be able to understand and communicate with the investigator and comply with the requirements of the study and had to give a written, signed and dated informed consent before any study assessment was performed. * Male or non-pregnant, non-lactating female patients ≥ 18 years of age. * Clinical diagnosis of active, moderate to severe TED (not sight-threatening) in the study eye at Baseline associated with 2 or more of the following: * Lid retraction \>= 2 mm * Moderate or severe soft tissue involvement * Exophthalmos \>= 3 mm above normal * Inconstant or constant diplopia * Onset of TED symptoms fewer than 12 months prior to Baseline. * CAS \>= 4 (on a 7-point scale, with a score of \>= 3 indicating active TED) in the more severely affected (study) eye at Screening and Baseline. Note: Proptosis is the primary qualifier for selection of the study eye. In case both eyes showed a similar degree of proptosis, other inflammatory signs and symptoms (CAS) were taken into account by the investigator for the selection of the study eye. * Peripheral euthyroidism or mild hypo-/hyperthyroidism defined as free T3 (fT3) and free T4 (fT4) \< 30% above/below normal limits at Screening. Every effort was to be made to correct the mild hypo-/hyperthyroidism promptly and to maintain the euthyroid state until the end of this study. * Orbital MRI assessment available confirming the diagnosis of TED for patients initially presenting with hypo- or euthyroidism (without treatment for hyperthyroidism) before or at the time of TED diagnosis (to rule out other potential causes of orbital signs and symptoms. Key Exclusion Criteria: * Improvement in CAS of \>= 2 points and/or improvement in proptosis of \>= 2 mm in the study eye between Screening and Baseline. * Signs of sight-threatening TED defined by optic neuropathy or severe corneal injury. * Patients, in the opinion of the investigator, requiring immediate or urgent medical treatment with glucocorticoids for TED. * Patients requiring immediate surgical ophthalmological intervention or planning corrective surgery/irradiation during the course of the study. * Decreased best corrected visual acuity (BCVA) as defined by a decrease in vision of 2 lines on the Snellen chart, new visual field defect or color defect within the last 6 months. * Any other ophthalmic and/or orbital disease or condition that might interfere with the assessment of TED. * Previous orbital radiotherapy. * Previous ophthalmological/orbital surgery for TED (e.g., orbital decompression). * Previous use of biological agents for the treatment of TED. * Previous use of systemic, non-biologic, immunomodulatory agents for the treatment of TED (e.g., mycophenolate or cyclosporine). * Previous exposure to secukinumab or other biologic drugs directly targeting IL-17A or the IL 17 receptor (e.g., ixekizumab, brodalumab). * Previous treatment with rituximab, tocilizumab or teprotumumab. * Previous use of systemic corticosteroids for the treatment of TED, except for oral corticosteroids with a cumulative dose equivalent to \< 1 g oral prednisone/prednisolone if the corticosteroid was discontinued at least 4 weeks prior to Baseline. * Previous treatment with any cell-depleting therapies including but not limited to anti-cluster of differentiation 20 (CD20) or investigational agents (e.g., CAMPATH, anti CD4, anti-CD5, anti-CD3, anti-CD19). * Use of other investigational drugs within 5 half-lives of enrollment or within 30 days, whichever is longer. * Previous or ongoing use of prohibited treatments (see Appendix 16.1.1-Protocol Section 6.2.2). Respective washout periods detailed in this section needed to be adhered to. * History of hypersensitivity to any of the study drug constituents. Other protocol defined Inclusion/Exclusion may apply.