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Second look surgery may spot hidden bladder cancer

NCT ID NCT07642102

Knowledge-focused Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether doing a second surgery soon after the first helps manage high-risk non-muscle invasive bladder cancer. 70 patients who had an initial tumor removal got an early second look procedure. The goal was to see if any cancer remained and what factors affected that. Results could guide better treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
early second look transurethral resection of bladder tumor (procedure)
What this could lead to
If successful, this could show that a second surgery soon after the first helps find leftover cancer and improve treatment decisions for high-risk bladder cancer.
What could go wrong
This is a small, completed study with 70 people, so results may not apply to everyone. It only looked at tumor presence, not long-term outcomes like survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

70 people

The number who actually took part.

Started

May 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

patients who underwent initial complete transurethral resection of bladder tumor with high risk non muscle invasive bladder cancer, recruited from the urology outpatient clinic, Urology department, Ain shams University.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients underwent initial complete resection TURBT with high risk non muscle invasive bladder cancer including: High grade T1 Any carcinoma in situ Any recurrent high grade Ta High grade Ta tumor size is more than 3 cm Any BCG failure in high grade patient Any variant histology Lymphovascular invasion High grade prostatic urethral involvement Exclusion Criteria: * \- Low risk non muscle invasive bladder cancer * intermediate risk non muscle invasive bladder cancer * muscle invasive bladder cancer * metastatic bladder cancer (positive lymph nodes or distant metastasis ) * absent muscle layer in the initial TURBT biopsies * incomplete resection initial TURBT

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Conditions

The condition(s) this trial relates to.

non-invasive bladder urothelial carcinoma superficial urinary bladder carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bladder (urothelial, transitional cell) cancer superficial (non-invasive) Transurethral resection of bladder tumor

Contacts and locations

Locations

  • Ain shams university

    Cairo, Cairo Governorate, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.