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Could a second ejaculate boost IVF success? new trial investigates

NCT ID NCT07056400

Knowledge-focused Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether using sperm from a second ejaculate (collected 1-2 hours after the first) can improve fertilization and embryo quality in ICSI, a type of IVF. Researchers will compare sperm quality and pregnancy outcomes between first and second ejaculates in 108 couples where the male partner has abnormal sperm. The goal is to see if this simple change can lead to better results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could offer a simple, non-invasive way to improve ICSI outcomes for couples with male infertility.
What could go wrong
This is a small, early-stage trial with no phase designation. Results may not apply to all infertility cases, and the approach may not significantly improve pregnancy rates.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 108 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2024

Expected to finish

Jan 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 45 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male: with abnormal semen parameter according to WHO. * Age range between 25-45 for both partners. Exclusion Criteria: * Female with factors that might affect Oocyte quality: Polycystic ovary (PCO). Poor ovarian reserve. Endometriosis. \- Male partners who need testicular biopsy to retrieve sperms.

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Conditions

The condition(s) this trial relates to.

male infertility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Male infertility

Contacts and locations

Locations

  • Nour El-Hayat Fertility Center

    Cairo, Cairo Governorate, 11762, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.