Could a simple change in dental sealant application keep Kids' teeth Cavity-Free longer?
NCT ID NCT06342258
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study tests whether curing (hardening) the bonding agent before placing dental sealants helps them stay on children's molars longer. Sealants are a standard way to prevent cavities, but they can wear off over time. Researchers will compare sealants placed with cured bond versus uncured bond in children aged 5 to 14, tracking retention for up to two years. The goal is to find a better method to protect teeth and reduce cavities.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ultradent Ultra Seal XT Plus
- What this could lead to
- If cured bond improves sealant retention, it could lead to better cavity prevention in children with fewer reapplications.
- What could go wrong
- This is an early-phase study with a small sample, so results may not apply to all children. The procedure involves standard risks like discomfort or sealant failure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 217 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2024
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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5 to 14 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ASA I and ASA II children, aged 5 to 14 years who are patients of CDHC and USC with adequate eruption of permanent first or second molars for placement of sealants * These teeth will not have previous restorations, interproximal lesions, pathology, or occlusal lesions. * Behavior of the children should be within a Frankl 3 or 4 category, indicating a "positive" and "Definitely Positive" behavior rating, which would allow for safe and controlled execution of the proposed protocol * Patient must have contralateral molars in the same arch in which sealants can be placed. For example a child with #30 and #19 present will qualify for the study. Exclusion Criteria * Any tooth with previous sealant placement * Children who are allergic or intolerant to sealant material * Children who cannot tolerate a dental suction isolation system, such as DryShield isolation * Children who do not complete a prophy cup polish. * Children who present with banded or bracketed molars * Patients or Parents who cannot fully understand an English or Spanish Consent/ Assent form. Withdrawal Criteria * Patients can withdraw voluntarily at any time. * Any tooth which has progression of caries beyond ICCMS Category 3 will be withdrawn from the study. These teeth will be treated with appropriate restorative dental treatment according to the standard of care. * Any qualifying tooth that subsequently requires a restoration due to trauma will be withdrawn from the study. * Any patient with an adverse reaction to treatment will be withdrawn. This event will be reported to the IRB.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Herman Ostrow School of Dentistry of USC
RECRUITINGLos Angeles, California, 90089, United States