Can a face filler fix loose belly skin after weight loss drugs?
NCT ID NCT07217743
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether Sculptra, a cosmetic injectable, can improve loose skin on the belly in people taking GLP-1 weight loss medications. Twenty women with mild to moderate skin laxity will receive Sculptra injections. Fifteen are on GLP-1 drugs, and five are not, to compare results.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Poly-L-lactic acid (Sculptra Aesthetic)
- What this could lead to
- If it works, this could offer a non-surgical option to tighten loose skin after weight loss from GLP-1 drugs.
- What could go wrong
- This is a small, early-phase study with only 20 participants. Results may not apply to everyone, and the treatment is cosmetic, not a cure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Oct 2025
An estimate. Start dates often move.
- Expected to finish
-
Oct 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
25 to 65 years
- Sex
-
Female participants only
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adult women aged 25-65 years. 2. Fitzpatrick skin types I-IV. 3. Presence of mild to moderate skin laxity of abdomen, as determined by clinical investigators. 4. Stable weight for 3 months, with body mass index (BMI) of 27 or less. 5. Current treatment with a stable dose of GLP-1 agonist medication for at least the last 6 months, for 15 of the enrolled subjects. Remaining 5 subjects should not be taking or have a history of taking a GLP-1 agonist medication, and should not be planning to take a GLP-1 in the foreseeable future. 6. Must be willing to sign a photography release and ICF, and complete the entire course of the study. 7. Subjects in good general health based on investigator's judgment and medical history. 8. Negative urine pregnancy test result at the time of study entry (if applicable). 9. Subjects of childbearing potential must agree to use an effective method of birth control during the entire course of the study. All systemic birth control measures must be in consistent use for at least 30 days prior to study enrollment. 1. Acceptable forms of birth control are: oral contraceptive pill, injection, implant, patch, vaginal ring, intrauterine device/coil, double-barrier methods (e.g., sponge, spermicide, or condoms). Abstinence and/or vasectomized partner must agree to a second acceptable method of birth control (double-barrier) should the subject become sexually active. 2. A female is considered of non-childbearing potential if she is: postmenopausal (no menses for at least 12 months), without a uterus (hysterectomy) and/or both ovaries (oophorectomy), or bilateral tubal ligation. Exclusion Criteria: 1. The presence of severe abdominal skin laxity as determined by clinical investigators. 2. Still actively losing weight. 3. Pregnancy or planned pregnancy during the study or currently breastfeeding. 4. Any uncontrolled systemic disease. 5. History of autoimmune connective tissue disease. 6. Current use of immunosuppressive medication. 7. Significant history or current evidence of a medical, psychological or other disorder that, in the investigator's opinion, would preclude enrollment into the study. 8. Active dermatitis or active infection in the proposed treatment area. 9. Mesotherapy; dermal fillers, biostimulator injectables; radiofrequency device treatments; microfocused ultrasound device treatments; laser and light-based device treatments; microneedling; cryolipolysis; high intensity focused electromagnetic energy device treatment; or surgery during the 12-month period before study treatment. 10. Any investigational treatment for skin quality of the abdomen during the 12-month period before the study treatment 11. Creams/cosmeceuticals and/or home therapies for the prevention or treatment of skin quality in the treatment area during the 1-month period before study treatment 12. Subjects with scarring in the treatment areas, including laparoscopic or abdominal surgery scars, which in the opinion of the investigator could impact results. Subjects with a history of keloids will be excluded. 13. Subjects who spray tanned or used sunless tanners in the treatment areas 1-month prior to study treatment. 14. History of bleeding disorder, concomitant use of anticoagulants, history of connective tissue disease (e.g., lupus, scleroderma), history of Bell's Palsy, epilepsy, smoking, and/or current pregnancy or breastfeeding . 15. Inability to ambulate following the procedure. 16. History of lidocaine and/or epinephrine sensitivity deemed by the investigator to preclude subject from enrolling into study. 17. Individuals with known allergies or sensitivities to any of the ingredients of any topical or injectable products being used in this study. 18. Current participation or participation within 30 days prior to the start of this study in a drug or other investigational research study.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Laxity; skin are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
West Dermatology Research Center
San Diego, California, 92121, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new serum tighten skin for women on ozempic?
- New device aims to smooth wrinkles without surgery
- New collagen injection aims to smooth wrinkles and plump skin
- One-Time radiofrequency treatment may lift jawline without surgery
- Ultrasound Face-Lift: new study tests deeper vs. shallow treatment for sagging skin
- New collagen filler aims to smooth wrinkles and scars