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Can a new serum tighten skin for women on ozempic?

NCT ID NCT07558603

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a topical serum called AGE serum on 50 post-menopausal women (ages 45-65) who are taking GLP-1 drugs like Ozempic or Wegovy, with half also on hormone therapy. The goal is to see if the serum safely improves skin firmness, fine lines, and radiance. Researchers will use skin grading scales and photos to measure changes over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
AGE serum (30% Proxylane, fruit-derived flavonoids, Cassia alata extract)
What this could lead to
If it works, this could offer a topical option to improve skin firmness, texture, and radiance for women experiencing skin laxity while on GLP-1 medications.
What could go wrong
This is a small, early-phase study with only 50 participants and no control group. Results may not apply to everyone, and the serum's effects on skin are subjective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 65 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Post-menopausal women (25 on HRT, 25 non HRT all must be post-menopausal) 2. Presence of mild to moderate signs of facial aging (e.g., fine lines, laxity, dull texture) based on modified Griffith scale. 3. Adult women aged 45-65 years. 4. Fitzpatrick skin types I-VI. 5. Current treatment with a stable dose of any GLP-1 agonist medication, including Ozempic, Rybelsus, or Wegovy for at least the last 3 months 6. Must be willing to sign a photography release and ICF,and complete the entire course of the study. 7. Subjects in good general health based on the investigator's judgment and medical history. Exclusion Criteria: 1. Non post-menopausal state. 2. Any uncontrolled systemic disease. 3. History of autoimmune connective tissue disease. 4. Current use of immunosuppressive medication. 5. Significant history or current evidence of a medical, psychological or other disorder that, in the investigator's opinion, would preclude enrollment into the study. 6. Active dermatitis or active infection in the proposed treatment area. 7. Mesotherapy; dermal fillers, biostimulator injectables; radiofrequency device treatments; microfocused ultrasound device treatments; cryolipolysis; high intensity focused electromagnetic energy device treatment; or surgery during the 12-month period before study treatment. 8. Microneedling treatments of the face and neck during the 1 month period before study treatment 9. Laser and light based device treatments of the face and neck. Ablative lasers 6-month period before study treatment, and 3-month period for non-ablative lasers. 10. Any neurotoxin injection to the face or neck during the 6-month period before study treatment 11. Subjects using any treatment skincare products must discontinue use of these products 2 weeks before the start of participating in this clinical study and for the duration of the study. 12. Subjects with scarring in the treatment areas, which in the opinion of the investigator could impact results. Subjects with a history of keloids will be excluded. 13. Subjects who spray tanned or used sunless tanners in the treatment areas 1-month prior to study treatment. 14. History of connective tissue disease (e.g., lupus, scleroderma), history of Bell's Palsy, history of smoking. 15. Inability to ambulate following the procedure. 16. Individuals with known allergies or sensitivities to any of the ingredients of any topical or injectable products being used in this study. 17. Current participation or participation within 30 days prior to the start of this study in a drug or other investigational research study.

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Conditions

The condition(s) this trial relates to.

cutis laxa Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • West Dermatology Research Center

    San Diego, California, 92121, United States

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