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New hope for lung cancer patients whose tumors outsmart current therapy

NCT ID NCT04606771

First seen Oct 31, 2025 · Last updated May 24, 2026 · Updated 27 times

Summary

This study tests whether adding savolitinib to the standard drug osimertinib can shrink tumors or slow cancer growth in people with a specific type of advanced lung cancer (EGFR mutation-positive and MET amplified) that has worsened despite osimertinib treatment. About 30 adults will be randomly assigned to receive either savolitinib plus osimertinib or savolitinib plus a placebo. The main goal is to see how many patients have their tumors shrink significantly.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Research Site

    Duarte, California, 91010, United States

  • Research Site

    Sacramento, California, 95817, United States

  • Research Site

    Ciudad de Buenos Aires, C1120AAT, Argentina

  • Research Site

    Delhi, 110085, India

  • Research Site

    Mumbai, 400053, India

  • Research Site

    Taichung, 402, Taiwan

  • Research Site

    Taipei, 100, Taiwan

  • Research Site

    Taipei, 11217, Taiwan

  • Research Site

    Taipei, 235, Taiwan

  • Research Site

    Taoyuan City, 333, Taiwan

  • Research Site

    Bangkok, 10210, Thailand

  • Research Site

    Bangkok, 10300, Thailand

  • Research Site

    Bangkok, 10330, Thailand

  • Research Site

    Bangkok, 10400, Thailand

  • Research Site

    Bangkok, 10700, Thailand

  • Research Site

    Hat Yai, 90110, Thailand

  • Research Site

    Khon Kaen, 40002, Thailand

  • Research Site

    Muang, 50200, Thailand

  • Research Site

    Hanoi, 100000, Vietnam

  • Research Site

    Hà Nội, 100000, Vietnam

  • Research Site

    Ho Chi Minh City, 700000, Vietnam

Conditions

Explore the condition pages connected to this study.