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How long does COVID immunity last? new study follows patients for a year

NCT ID NCT04637867

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed study looked at 189 adults who had COVID-19 to see how long their immune system remembers the virus. Researchers collected blood, saliva, and nose swabs at 6 and 12 months after infection to measure antibody levels. The goal was to understand if protective immunity lasts and how strong it is over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help clarify how long natural immunity lasts after a COVID-19 infection.
What could go wrong
This is an observational study with no treatment, so it cannot directly lead to a cure or therapy. Results may not apply to new variants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

189 people

The number who actually took part.

Started

Nov 2020

Finished

May 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: SARS-CoV-2 confirmed by RT-PCR * Adults \> 18 years * Signed consent form * Affiliated to the French health system Exclusion Criteria: * Pregnant women * Hospitalized patients * Individuals subject to legal protection * Imprisoned individuals * Individuals who have expressed an opposition to participate, or who do not wish to donate blood samples

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Conditions

The condition(s) this trial relates to.

COVID-19 viral infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infection viral

Contacts and locations

Locations

  • Service épidémiologie, Hopital édouard Herriot

    Lyon, Rhone, 69003, France

  • hopital Edouard Herriot

    Lyon, 69003, France

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