New combo therapy aims to tackle tough sarcomas

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age: 18-75 years old, both genders are eligible. 2. Pathological Diagnosis: Histologically confirmed soft tissue sarcoma, including but not limited to: * Undifferentiated pleomorphic sarcoma * Liposarcoma * Leiomyosarcoma * Synovial sarcoma * Fibrosarcoma * Other high-grade soft tissue sarcomas 3. Disease Stage: * Locally advanced, unresectable soft tissue sarcoma, or * Recurrent or metastatic soft tissue sarcoma 4. Prior Therapy: * Prior surgery, radiotherapy, or chemotherapy is allowed. * At least 4 weeks since the last anti-tumor treatment. * Prior treatment-related toxicities have resolved to ≤Grade 1 (except alopecia). 5. Measurable Disease: At least one measurable lesion according to RECIST 1.1 criteria. 6. Performance Status: ECOG performance status score of 0-2. 7. Life Expectancy: ≥3 months. 8. Organ Function: * Hematology: Hemoglobin ≥50 g/L, absolute neutrophil count ≥1.5×10⁹/L, platelet count ≥60×10⁹/L * Liver Function: Total bilirubin ≤1.5× upper limit of normal (ULN), ALT and AST ≤2.5× ULN (≤5× ULN for patients with liver metastasis) * Renal Function: Serum creatinine ≤1.5× ULN or creatinine clearance ≥50 mL/min * Cardiac Function: Left ventricular ejection fraction ≥40% 9. Informed Consent: The patient or their legal representative has signed the informed consent form. Exclusion Criteria: 1. Special Types of Sarcoma: * Gastrointestinal Stromal Tumor (GIST) * Osteosarcoma * Ewing's Sarcoma 2. Prior Treatment History: * Previous radiotherapy to the same site with a cumulative dose that may exceed the normal tissue tolerance dose * Major surgery within 4 weeks 3. Concurrent Diseases: * Active autoimmune diseases * Diseases requiring systemic immunosuppressive therapy * Severe cardiovascular diseases (myocardial infarction, unstable angina, heart failure, etc.) * Severe pulmonary diseases (interstitial pneumonia, pulmonary fibrosis, etc.) * Active infections requiring systemic anti-infective therapy 4. Central Nervous System Metastasis: Symptomatic brain or spinal metastasis. 5. Pregnancy and Lactation: Women who are pregnant or breastfeeding. 6. Allergy History: Known allergies to the drugs or their components involved in the study.