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Go home the same day after appendix surgery? new study says it might be just as safe

NCT ID NCT05691348

Symptom relief Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares same-day discharge versus staying overnight in the hospital after laparoscopic surgery for uncomplicated appendicitis. About 1,400 patients aged 15 to 74 with mild appendicitis will take part. The goal is to see if going home the same day is just as safe and leads to similar recovery within 30 days.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2023

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 74 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 15-74 years * BMI ≤ 35 kg/m2 * Uncomplicated acute appendicitis confirmed by imaging (ultrasound and/or CT and/or MRI) * Temperature ≤ 38,1°C and \> 35,5°C * Appendix diameter \> 6mm and ≤ 15mm * Without effusion or with only localized peri-appendicular effusion * Infiltration of peri-appendicular fat without abscess or plastron * No sign of perforation * Leukocytes ≤ 18,000G/L AND * CRP (C reactive protein) ≤ 60mg/L * If pain, calmed by level 3 analgesic at maximum * Ambulatory criteria * Availability of monitoring by a relative during the 12 hours after discharge from the hospital * Residence located less than 20 minutes by car from a health center (hospital or clinic) * Access to a telephone mobile or fixed in case of problems * Signature of the written informed consent form by the patient * If the patient is a minor, signature of the written informed consent form by both parents or their legal representative * Affiliation to a French health insurance scheme or equivalent Exclusion Criteria: * Criteria that exclude ambulatory care such as an ASA score (Physical status score) \> 2, severe or uncontrolled comorbidities, severe pulmonary disease including obstructive sleep apnea, anticoagulation or antiplatelet drug or contraindication to ambulatory surgery such as intubation difficulties * Presence of active cancer, a malignant hemopathy, drug addiction, coagulopathy, immunosuppressive treatment * Non-acute or interval appendectomy, i.e. after antibiotic treatment of a complicated appendicitis of the plastron or drainage of an appendicular abscess; * History of pelvic surgery * Vulnerable people: pregnant or breast-feeding women (patients will undergo a pregnancy test: plasmatic β-hCG (human chorionic gonadotropin) or urinary test), adult under guardianship or deprived of freedom. Pregnant women are considered to have a full stomach, with risk of inhalation at anesthetic induction and represent a contraindication to ambulatory surgery. In addition, the need to perform abdominal surgery on a pregnant woman requires obstetric monitoring that is difficult to reconcile with management in an outpatient surgery unit (need for obstetric ultrasound or monitoring). * Suspicion of a tumor of the appendix : Mucocele and pseudomyxoma, Carcinoid tumor, Adenocarcinoma of the appendix, Another type of tumor

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Conditions

The condition(s) this trial relates to.

appendicitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Appendicitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    33 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • APHM Hôpital Nord

    RECRUITING

    Marseille, Bouches-du-Rhône, 13326, France

  • APHP Lariboisière

    RECRUITING

    Paris, Île-de-France Region, 75475, France

  • APHP Pitié Salpetrière

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75013, France

  • CH de Dax

    RECRUITING

    Dax, New Aquitaine, 40107, France

  • CH de Mont de Marsan

    RECRUITING

    Mont-de-Marsan, New Aquitaine, 40000, France

  • CH de Troyes

    NOT_YET_RECRUITING

    Troyes, Aube, 10000, France

  • CH de Voiron

    RECRUITING

    Voiron, Auvergne-Rhône-Alpes, 38500, France

  • CHU Amiens-Picardie

    RECRUITING

    Amiens, Hauts-de-France, 80054, France

  • CHU Grenoble Alpes

    RECRUITING

    La Tronche, Auvergne-Rhône-Alpes, 38700, France

  • CHU Minjo

    NOT_YET_RECRUITING

    Besançon, Bourgogne-Franche-Comté, 25000, France

  • CHU d'Angers

    RECRUITING

    Angers, Pays de la Loire Region, 49933, France

  • CHU de Bordeaux

    NOT_YET_RECRUITING

    Bordeaux, Aquitaine, 33076, France

  • CHU de La Réunion

    RECRUITING

    Saint-Denis, La Réunion, 97400, Reunion

  • CHU de La Réunion

    RECRUITING

    Saint-Pierre, La Réunion, 97448, Reunion

  • CHU de Nice

    RECRUITING

    Nice, Alpes-Maritimes, 06000, France

  • CHU de Reims

    NOT_YET_RECRUITING

    Reims, Marne, 51100, France

  • CHU de Rennes

    NOT_YET_RECRUITING

    Rennes, Brittany Region, 35000, France

  • CHU de Saint-Etienne - Hôpital Nord

    RECRUITING

    Saint-Priest-en-Jarez, Auvergne-Rhône-Alpes, 42270, France

  • CHU de Tours

    NOT_YET_RECRUITING

    Tours, Indre Et Loire, 37044, France

  • Clinique de Saint-Omer

    NOT_YET_RECRUITING

    Blendecques, Hauts-de-France, 62575, France

  • Clinique de l'Estrée

    NOT_YET_RECRUITING

    Stains, Île-de-France Region, 93240, France

  • Clinique du Val d'Ouest

    NOT_YET_RECRUITING

    Écully, Rhones-Alpes, 69130, France

  • HIA Percy

    NOT_YET_RECRUITING

    Clamart, Hauts-de-Seine, 92140, France

  • Hia Begin

    NOT_YET_RECRUITING

    Saint-Mandé, Île-de-France Region, 94160, France

  • Hôpital Avicenne

    RECRUITING

    Bobigny, Île-de-France Region, 93000, France

  • Hôpital Beaujon (APHP)

    NOT_YET_RECRUITING

    Clichy, Hauts de Seine, 92110, France

  • Hôpital Cochin APHP

    NOT_YET_RECRUITING

    Paris, Paris, 75014, France

  • Hôpital Edouard HERRIOT

    RECRUITING

    Lyon, Auvergne-Rhône-Alpes, 69003, France

  • Hôpital Louis-Mourier

    NOT_YET_RECRUITING

    Colombes, Île-de-France Region, 92700, France

  • Hôpital Robert Debré - CHU de Reims

    RECRUITING

    Reims, Grand Est, 51092, France

  • Hôpital d'Instruction des armées Laveran

    RECRUITING

    Marseille, Provence-Alpes-Côte d'Azur Region, 13384, France

  • Hôpital d'Instruction des armées Sainte Anne - BCRM Toulon

    RECRUITING

    Toulon, Provence-Alpes-Côte d'Azur Region, 83800, France

  • Hôpitaux Pédiatriques de Nice CHU - Lenval

    NOT_YET_RECRUITING

    Nice, Alpes Maritimes, 06200, France

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