Saliva test may replace needles for orthodontic monitoring
NCT ID NCT07303647
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether saliva can be used to track bone changes in people getting braces. Researchers will measure genes related to bone metabolism in saliva samples from 24 patients aged 15-25 with moderate crowding. The goal is to find a non-invasive way to monitor how teeth move during treatment, avoiding the need for blood tests or tissue samples.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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24 people
The number who actually took part.
- Started
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Oct 2025
- Expected to finish
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Feb 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Twenty-four patients (mean age 18.5 ± 3.2 years) who were receiving fixed orthodontic care were enrolled in this investigation.
- Ages
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15 to 25 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: 1.15 to 25 years of age 2.moderate crowding (3-6 mm) 3.generally good health with no systemic conditions that could influence bone metabolism 4. no recent use of medications known to affect bone metabolism (such as bisphosphonates and corticosteroids) or any other NSAIDs. Exclusion criteria: 1. periodontal disease 2. smoking or any form of tobacco use 3. pregnancy or lactation 4. prior orthodontic treatment 5. craniofacial syndromes 6. The use of antibiotics within 3 months before the study. -
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hawler teaching hospital
Erbil, Ervil, 44001, Iraq
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