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Saline bubbles may offer simpler heart monitoring in the ICU

NCT ID NCT04310904

Diagnosis Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study explores whether injecting a small amount of agitated saline (salt water mixed with air bubbles) during an ultrasound of the heart can accurately measure how much blood the heart pumps. The method aims to be simpler and less dependent on the operator's skill than current techniques. Participants are intensive care patients who already need a heart ultrasound and a saline contrast test as part of their care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
agitated saline contrast
What this could lead to
If successful, this could provide a simpler, more consistent way to measure heart function in intensive care without relying on manual measurements.
What could go wrong
This is a small, early-stage study focused on feasibility and correlation with existing methods. The technique may not prove accurate enough to replace current standards.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Started

Mar 2019

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

all ICU patients intubated/ventilated with a central line and an arterial catheter who need trans esophageal echocardiography examination with a saline contrast test.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * all ICU patients intubated/ventilated with a central line and an arterial catheter who need trans esophageal echocardiography examination with a saline contrast test. Exclusion Criteria: * patients under 18 years old * pregnant patients * moribund patients

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Echocardiography

Contacts and locations

Locations

  • CHU Amiens

    Amiens, 80480, France

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