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Can a daily sage pill keep Middle-Aged minds quick?

NCT ID NCT07757529

Symptom relief Sponsor: ESM Technologies, LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This trial tests whether a daily sage extract supplement, called SageXtra, can improve memory, attention, and reaction time in healthy middle-aged men and women. Participants take either the sage supplement or a placebo for a period, then complete a series of computer-based mental tasks. The goal is to see if this natural herb, known for antioxidant properties, offers a simple way to support cognitive function as we age.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
SageXtra, a sage (Salvia officinalis) extract powder taken as 333 mg daily in capsule form
What this could lead to
If it works, this could point toward a natural supplement to help middle-aged adults maintain or improve everyday memory and mental sharpness.
What could go wrong
This is a small, early-stage trial, and results may not apply to everyone. Sage supplements can have side effects, and the benefit over placebo may be minimal.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 64 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI 18.5-34.9 (inclusive) with a goal of being \< 30 on average * Subject agrees to maintain their existing dietary patterns throughout the study period. * Subject agrees to refrain from alcohol, caffeine, and strenuous exercise for 24 hours before each test day. * Subject is willing and able to comply with the study protocol. * Has given voluntary, written, informed consent to participate in the study. Exclusion Criteria: * Individuals with a personal history of a psychiatric disorder. * Individuals who are determined to have liver, renal, cardiovascular, or other metabolic disease. * Current or recent (\< 4 weeks) use of any dietary supplements (e.g., choline, lecithin, ginseng, ginkgo biloba, ashwagandha, Bacopa Monnieri, Paullina cupana, Rhodiola rosea, L-theanine, omega-3 fats, Prevagen, etc.), or currently prescribed medications (e.g., Adderall, Mydayis, Ritalin, Concerta, Mythylin, Provigil, Namenda), that may affect cognitive function (focus, concentration, memory, reaction time, energy, etc.). * Alcohol consumption (\>2 standard alcoholic drinks/day or \>10 drinks/week) or drug abuse/dependence (including regular marijuana or THC use). * Currently a smoker. * Allergy or sensitivity to study product ingredients. * Individuals who are cognitively impaired and/or who are unable to give informed consent. * Any other condition which, in the PI's opinion, may adversely affect the subject's ability to complete the study, its measurements, or pose a significant risk to the subject.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive ability general

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Exercise & Sport Nutrition Lab - Texas A&M University

    RECRUITING

    College Station, Texas, 77843, United States

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