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Foster care before age 2 could rewire brains of orphaned kids, study hints

NCT ID NCT00747396

Knowledge-focused Sponsor: Charles Alexander Nelson III Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 136 children from Romania who were placed in foster care after living in institutions. Researchers track their thinking skills, emotional health, brain activity, and social behavior into young adulthood. The goal is to understand whether early foster care can improve long-term outcomes for children who experienced severe neglect.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Foster care placement
What this could lead to
If successful, this study could show that early foster care helps reverse some effects of institutional deprivation on brain development and mental health.
What could go wrong
This is an observational follow-up, not a treatment trial. Results may not apply to other settings or populations, and individual outcomes vary widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

136 people

The number who actually took part.

Started

Sep 2000

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 24 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for assessment at age 21 years: * previously institutionalized and community children that took part in previous BEIP assessments * target recruitment age is +/- 6 mos of 21st birthday Exclusion Criteria for assessment at age 21 years: * open or closed head injury within the past 12 months * viral or bacterial meningitis within the past 12 months

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Conditions

The condition(s) this trial relates to.

CGF1 Health Behavior Language psychiatric disorder Risk-Taking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain function Cognitive ability general Executive function Health behavior Psychiatric and/or mood disorders Risk-taking Social cognition

Contacts and locations

Locations

  • Fundatia Tanner

    Bucharest, 011467, Romania

More trials for these conditions

Other studies related to the condition(s) this trial covers.