New combo therapy aims to tame overactive immune system with fewer side effects
NCT ID NCT06160791
First seen Jan 04, 2026 · Last updated May 17, 2026 · Updated 21 times
Summary
This study tests a new combination of drugs for adults newly diagnosed with hemophagocytic lymphohistiocytosis (HLH), a rare condition where the immune system attacks the body. The treatment uses ruxolitinib plus a shorter, lower-dose course of standard therapy (dexamethasone and etoposide) to try to control the disease while reducing toxic side effects. About 36 adults will take part to see if this approach works and is safer.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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University of California Davis Comprehensive Cancer Center
RECRUITINGSacramento, California, 95817, United States
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University of California, Irvine
RECRUITINGIrvine, California, 92697, United States
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
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Conditions
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