New approach tested for dangerous transplant complication
NCT ID NCT06936566
Summary
This study is testing a drug called ruxolitinib as the first treatment for acute graft-versus-host disease (GVHD), a serious complication that can occur after a bone marrow transplant. Researchers want to see if ruxolitinib alone works as well as steroid-free therapy for lower-risk patients, and if adding it to steroids improves outcomes for higher-risk patients. The trial will enroll 98 adults who developed GVHD after transplant and will compare different doses to find the most effective one with the fewest side effects.
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Contacts and locations
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Study contacts
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Locations
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City of Hope Comprehensive Cancer Center
RECRUITINGDuarte, California, 91010, United States
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Dana Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02115, United States
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Fred Hutchinson Cancer Research Center
RECRUITINGSeattle, Washington, 98109, United States
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
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Kansas University Medical Center
RECRUITINGFairway, Kansas, 66205, United States
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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Moffitt Cancer Center
NOT_YET_RECRUITINGTampa, Florida, 33612, United States
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Ohio State University
NOT_YET_RECRUITINGColumbus, Ohio, 43210, United States
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University of Pennsylvania
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Vanderbilt University
RECRUITINGNashville, Tennessee, 37235, United States
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Washington University
NOT_YET_RECRUITINGSt Louis, Missouri, 63110, United States
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Winship Cancer Institute, Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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Conditions
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