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Shocking the nose back to life: new combo therapy for Parkinson's smell loss

NCT ID NCT07666477

Symptom relief Sponsor: Mustafa Baran Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether combining a non-invasive brain stimulation technique (rTMS) with daily smell training could help people with Parkinson's disease recover their sense of smell and taste. 120 participants were split into four groups to compare the combo therapy against each treatment alone or a sham. The goal was to see if the combined approach leads to better sensory recovery, measured by standard smell tests.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS) and structured olfactory training
What this could lead to
If it works, this could offer a non-drug way to help people with Parkinson's regain their sense of smell and taste, improving daily life.
What could go wrong
This is a small, completed trial. The results may not apply to everyone, and the improvements might be modest or not last long. rTMS can cause mild side effects like headache or scalp discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

120 people

The number who actually took part.

Started

Jan 2026

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged between 40 and 75 years. * Confirmed diagnosis of idiopathic Parkinson's disease (PD) according to the Movement Disorder Society (MDS) clinical diagnostic criteria. * Confirmed olfactory dysfunction validated by the Sniffin' Sticks test at baseline (defined as a composite TDI score ≤ 30.5 for hyposmia and \< 16.0 for functional anosmia). Exclusion Criteria: * Presence of cranial metal implants or cardiac pacemakers (absolute contraindications for rTMS). * Pregnancy. * Severe psychiatric disorders. * Advanced dementia. * History of nasal polyps or active sinusitis that could mechanically obstruct olfactory pathways.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Olfactory dysfunction Parkinson disease (PD)

Contacts and locations

Locations

  • Batman University

    Batman, Batman, 72060, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.