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RSV booster shot shows promise for seniors

NCT ID NCT07117487

First seen Feb 02, 2026 · Last updated Jun 19, 2026 · Updated 27 times

Summary

This study tested a new mRNA booster shot (mRNA-1345) in 507 adults aged 60 and older who had already received a licensed RSV vaccine at least a year earlier. The goal was to see if the booster is safe and boosts the immune system's ability to fight RSV. Researchers measured side effects and antibody levels in the blood.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Indago Research & Health Center, Inc.

    Hialeah, Florida, 33012, United States

  • Velocity Clinical Research, Austin

    Austin, Texas, 78759, United States

  • Velocity Clinical Research, Covington

    Covington, Louisiana, 70433, United States

  • Velocity Clinical Research, Denver

    Denver, Colorado, 80110, United States

  • Velocity Clinical Research, Hampton

    Hampton, Virginia, 23666, United States

  • Velocity Clinical Research, Lincoln

    Lincoln, Nebraska, 68510, United States

  • Velocity Clinical Research, Medford

    Medford, Oregon, 97504, United States

  • Velocity Clinical Research, Rockville

    Rockville, Maryland, 20854, United States

  • Velocity Clinical Research, Savannah

    Savannah, Georgia, 31406, United States

  • Velocity Clinical Research, Spokane

    Spokane, Washington, 99218, United States

  • Velocity Clinical Research, Valparaiso

    Valparaiso, Indiana, 46383, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

mRNA-1345 (an mRNA-based RSV vaccine booster)

What this could lead to

If successful, this could show that an mRNA booster safely strengthens protection against RSV in older adults who already received a different RSV vaccine.

What could go wrong

This is a completed phase 3 study, but results are not yet published. The booster may not provide significantly better immunity than the original vaccine, and side effects like injection site pain or fever are possible.

Conditions

The condition(s) this trial relates to.

respiratory syncytial virus infectious disease viral infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.