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New eczema pill shows promise in Mid-Stage trial

NCT ID NCT05399368

Symptom relief Sponsor: RAPT Therapeutics, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental daily pill called RPT193 for adults with moderate-to-severe atopic dermatitis (eczema) that didn't improve with topical creams. The goal was to see if it reduces skin redness, swelling, and itchiness over 16 weeks. The trial involved 229 participants and was stopped early, but results help researchers understand how well the drug works and its safety.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

229 people

The number who actually took part.

Started

Jun 2022

Finished

May 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinically confirmed diagnosis of active atopic dermatitis (AD), according to the revised Hanifin and Rajka criteria * 12-month history of AD and had no significant flares in AD for at least 4 weeks before screening * inadequate response to a ≥1 month treatment with topical medications * Atopic dermatitis covering ≥10% of the body surface area * EASI score ≥16 * Validated Investigator Global Assessment (VIGA) ≥3 * Use of emollient(s) at least 2x daily for 1 week prior to baseline * Negative coronavirus disease (COVID)-19 results at screening Exclusion Criteria: * Uncontrolled moderate-to-severe asthma * Uncontrolled diabetes * Stage III or IV cardiac failure * Severe renal condition * Major surgery within 8 weeks of screening * Immunodeficiency and/or receipt of immunosuppressive drugs within 4 weeks of baseline * Use of systemic Janus kinase (JAK) inhibitor within 8 weeks of baseline * Received live or live-attenuated vaccine within 4 weeks of baseline * Prior receipt of RPT193

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Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atopic dermatitis

Contacts and locations

Locations

  • Acclaim Dermatology

    Sugar Land, Texas, 77479, United States

  • Advanced Dermatology of the Midlands

    Omaha, Nebraska, 68144, United States

  • Apex Clinical Research Center

    Mayfield Heights, Ohio, 44124, United States

  • Arkansas Research Trials, LLC

    North Little Rock, Arkansas, 72117, United States

  • Arlington Research Center Inc.

    Arlington, Texas, 76011, United States

  • Beacon Clinical Research, LLC

    Quincy, Massachusetts, 02169, United States

  • Cahaba Dermatology and Skin Health Center

    Birmingham, Alabama, 35244, United States

  • California Dermatology & Clinical Research Institute

    Encinitas, California, 92024, United States

  • Clinical Science Institute

    Santa Monica, California, 90404, United States

  • Clinical Trial Network

    Houston, Texas, 77074, United States

  • Clinical Trials Research Institute

    Thousand Oaks, California, 91320, United States

  • Complete Dermatology

    Sugar Land, Texas, 77479, United States

  • Dawes Fretzin Clinical Research Group, LLC

    Indianapolis, Indiana, 46250, United States

  • DelRicht Research

    Baton Rouge, Louisiana, 70809, United States

  • DermResearch

    Austin, Texas, 78759, United States

  • Dermatology Research Associates

    Los Angeles, California, 90045, United States

  • Dermatology Treatment and Research Center

    Dallas, Texas, 75230, United States

  • Driven Research LLC

    Coral Gables, Florida, 33134, United States

  • First OC Dermatology

    Fountain Valley, California, 92708, United States

  • Fivenson Dermatology

    Ann Arbor, Michigan, 48103, United States

  • Florida Academic Centers Research and Education, LLC

    Coral Gables, Florida, 33134, United States

  • Forcare Clinical Research

    Tampa, Florida, 33613, United States

  • Forest Hills Dermatology Group

    Kew Gardens, New York, 11415, United States

  • Foxhall Research Center

    Washington D.C., District of Columbia, 20016, United States

  • GSI Clinical Research

    Margate, Florida, 33063, United States

  • Georgia Skin & Cancer Clinic

    Savannah, Georgia, 31419, United States

  • Grekin Skin Institute

    Warren, Michigan, 48088, United States

  • Grimes Center

    Los Angeles, California, 90036, United States

  • Health Concepts

    Rapid City, South Dakota, 57702, United States

  • Ichan School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Indiana Clinical and Translational Sciences Institute (CTSI) Clinical Research Center

    Indianapolis, Indiana, 46202, United States

  • Integrative Skin Science and Research

    Sacramento, California, 95815, United States

  • JUVA Skin & Laser Center

    New York, New York, 10022, United States

  • Jordan Valley Dermatology Center

    South Jordan, Utah, 84095, United States

  • LEADER Research

    Hamilton, Ontario, L8L 3C3, Canada

  • Lenus Research & Medical Group, LLC

    Sweetwater, Florida, 33172, United States

  • Marietta Dermatology Clinical Research, Inc.

    Marietta, Georgia, 30060, United States

  • Markowitz Medical, PLLC

    New York, New York, 10128, United States

  • Medisearch Clinical Trials

    Saint Joseph, Missouri, 64506, United States

  • MetroBoston Clinical Partners

    Brighton, Massachusetts, 02135, United States

  • Optima Research - Boardman

    Boardman, Ohio, 44512, United States

  • Palm Beach Dermatology Group

    Delray Beach, Florida, 33484, United States

  • Perseverance Research Center

    Scottsdale, Arizona, 85254, United States

  • Premier Clinical Research

    Spokane, Washington, 99202, United States

  • Progressive Clinical Research

    San Antonio, Texas, 78213, United States

  • Red Maple Trials Inc.

    Ottawa, Ontario, K1H 1E4, Canada

  • Schweiger Dermatology Group

    Verona, New Jersey, 07044, United States

  • Schweiger Dermatology Group, PC Research Division

    Columbia, Maryland, 21044, United States

  • SimcoDerm Medical and Surgical Dermatology Center

    Barrie, Ontario, L4M7G1, Canada

  • Skin Care Physicians of Georgia

    Macon, Georgia, 31217, United States

  • Skin Sciences PLLC

    Louisville, Kentucky, 40217', United States

  • Skin Specialists PC (Schlessinger MD)

    Omaha, Nebraska, 68144, United States

  • St. Joseph Dermatology and Vein Clinic

    Saint Joseph, Michigan, 49085, United States

  • Studies in Dermatology, LLC

    Cypress, Texas, 77433, United States

  • The Indiana Clinical Trials Center PC

    Plainfield, Indiana, 46168, United States

  • University Dermatology and Vein Clinic

    Darien, Illinois, 60561, United States

  • Velocity Clinical Research

    North Hollywood, California, 91606, United States

  • Wallace Medical Group

    Los Angeles, California, 90056, United States

  • West End Dermatology Associates

    Richmond, Virginia, 23233, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.