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Could a rose fruit powder ease pain after knee replacement?

NCT ID NCT07395856

Symptom relief Sponsor: Shuguang Gao Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a powder made from Rosa roxburghii (a type of rose fruit) can help people recover after total knee replacement surgery for osteoarthritis. 184 participants will take either the supplement or a placebo daily for 30 days after surgery. Researchers will measure inflammation, oxidative stress, pain, and knee function to see if the supplement improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Rosa roxburghii (rose fruit) juice freeze-dried powder
What this could lead to
If it works, this could point toward a natural supplement to help people recover faster and with less pain after knee replacement surgery.
What could go wrong
This is a small, early-stage trial with only 184 participants, and it uses a dietary supplement, not a drug. The results may not be strong enough to recommend it widely, and the placebo effect could play a role.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 184 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * diagnostic criteria for primary knee osteoarthritis (KOA) as defined by the "Chinese Guidelines for the Diagnosis and Treatment of Osteoarthritis (2019 Edition)." * Aged between 18 and 75 years. * No history of trauma or surgery involving the lower limbs. Scheduled to undergo total knee arthroplasty (TKA) performed by the same surgical team at the participating hospital. * Willing to refrain from participating in any other clinical research studies for the duration of this trial. * Agrees to adhere to the complete study treatment regimen. * Able and willing to provide written informed consent. Exclusion Criteria: * Has a preoperative knee joint infection, rheumatoid arthritis, or other concurrent inflammatory or non-inflammatory joint disease. * Has a history of any prior knee surgery (including revision procedures). * Has diabetes mellitus with poorly controlled glucose levels (fasting blood glucose \>7.2 mmol/L or 2-hour postprandial blood glucose \>11.1 mmol/L). Has severe, unstable, or uncontrolled disease of the circulatory, respiratory, or hematopoietic systems. * Has obesity defined as a body mass index (BMI) ≥30 kg/m². * Has a diagnosis of severe osteoporosis. * Is pregnant or currently breastfeeding. * Has an active psychiatric disorder or any other condition that, in the investigator's judgment, would impair the ability to provide informed consent or comply with study procedures.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis

How to take part

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  1. The official record

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    Open the record ↗

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