Which root canal filling hurts least? new study has answers
NCT ID NCT06795282
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested three different root canal filling materials in 54 people with inflamed tooth pulp to see which caused the least pain after a single-session root canal. Patients rated their pain over 7 days. The goal is to find a material that makes root canals more comfortable.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- MTA (a biocompatible cement used in root canals)
- What this could lead to
- If one material clearly causes less pain, dentists may adopt it to make root canals more comfortable.
- What could go wrong
- This is a small, completed trial with only 54 participants, so results may not apply to everyone. Pain is subjective and hard to measure precisely.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
54 people
The number who actually took part.
- Started
-
Jan 2025
- Finished
-
Dec 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Systemically healthy patients between the ages of 18-65
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * asymptomatic tooth with delayed positive response to thermal tests and electric pulp tests * large pulp perforation during caries removal, * inflamed pulp in which bleeding could not be controlled within 5 min, * periodontally healthy mature mandibular first or second molar tooth. Exclusion Criteria: * patients if they were diabetic, immunocompromised, pregnant, * had a positive history of antibiotic use during the past 1 month, * required antibiotic prophylaxis * used analgesic within 7 days prior to the beginning of treatment, * were allergic to the materials used during root canal treatment, * if the bleeding could be controlled within 5 min and vital pulp treatment could be performed, * the tooth had negative response to vitality tests and/or was symptomatic, * had an associated periapical lesion visible on a radiograph, * needed a post-core or was planned to serve as prosthetic support, * had a calcified root canal and internal or external root resorption, * had tooth with open apex * mandibular third molars
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Erciyes University Faculty of Dentistry
Kayseri, 38000, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a Flat-Sided dental file mean less pain after a root canal?
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- Could a new filling material save baby teeth when adult teeth are missing?