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New pill could ease painful skin lumps for those failed by antibiotics

NCT ID NCT07228390

Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 02, 2026 · Updated 4 times

Summary

This study tests a daily pill called ritlecitinib for adults with moderate to severe hidradenitis suppurativa (HS), a condition causing painful red skin lumps. About 240 participants who haven't been helped by antibiotics will be randomly assigned to get the drug or a placebo for 16 weeks. Researchers will compare how many people see at least a 50% reduction in their HS symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ritlecitinib (a daily oral pill)
What this could lead to
If it works, this could point toward a new treatment option for people with moderate to severe hidradenitis suppurativa who haven't been helped by antibiotics.
What could go wrong
This is an early Phase 2 trial with only 240 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

128 people

The number who actually took part.

Started

Nov 2025

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Eligibility Criteria: Inclusion Criteria: 1. Male or female participants ≥18 to ≤75 years of age. 2. Participants with a diagnosis (based on clinical history and physical examination) of moderate to severe HS for at least 6 months prior to Screening Visit and inadequate response to at least 4-week (28 days) treatment with oral antibiotics for the treatment of HS. Exclusion Criteria: 1. Presence of ≥20 draining fistulae at Screening or BL visit 2. Evidence of other active skin disease or condition at screening 3. Have a known immunodeficiency disorder 4. Having a history of systemic infection requiring hospitalization or parenteral therapy, including history of infection with Mycobacterium TB 5. Specific Viral Infection History (incl. history of herpes zoster, HBV or HCV Infection 6. Current or recent history of clinically significant severe, progressive, or uncontrolled other medical conditions 7. Any medical or psychiatric condition including any active suicidal ideation in the past year or suicidal behavior in the past 5 years

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Conditions

The condition(s) this trial relates to.

hidradenitis suppurativa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hidradenitis suppurativa

Contacts and locations

Locations

  • Advanced Medical Research, PC.

    Sandy Springs, Georgia, 30328, United States

  • Alliance Clinical Research of Tampa

    Tampa, Florida, 33615, United States

  • Athens Medical Center - Psychikon branch

    Athens, Attica, 11525, Greece

  • Burke Pharmaceutical Research

    Hot Springs, Arkansas, 71913, United States

  • CHOP-Centro De Especialidades De Mollabao

    Pontevedra, 36001, Spain

  • CaRe Clinic

    Red Deer, Alberta, T4P 1K4, Canada

  • Center for Clinical Studies, LTD. LLP

    Houston, Texas, 77004, United States

  • Centre de Recherche Saint-Louis inc.

    Québec, G1W 4R4, Canada

  • Centrum Zdrowia Dziecka i Rodziny im Jana Pawla II w Sosnowcu

    Sosnowiec, 41-200, Poland

  • Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spółka Partnerska

    Wroclaw, Lower Silesian Voivodeship, 50-566, Poland

  • ClinOhio Research Services

    Columbus, Ohio, 43213, United States

  • Columbia Dermatology & Aesthetics

    Columbia, South Carolina, 29212, United States

  • D&H Tamarac Research Center

    Tamarac, Florida, 33321, United States

  • DAR Clinical Research

    Ottawa, Ontario, K1V 1C1, Canada

  • DS Research of Kentucky

    Louisville, Kentucky, 40241, United States

  • Dermatological and Venereological Hospital Andreas Syggros

    Athens, 16121, Greece

  • Dermatology Research Institute

    Calgary, Alberta, T2J 7E1, Canada

  • Dermedic Jacek Zdybski

    Ostrowiec Świętokrzyski, 27-400, Poland

  • Endeavor Health

    Skokie, Illinois, 60077, United States

  • Essential Medical Research - Overland Park

    Overland Park, Kansas, 66213, United States

  • Eurofins CRL

    Forest, Virginia, 24551, United States

  • FACET Dermatology

    Toronto, Ontario, M4E 1R7, Canada

  • First OC Dermatology Research Inc

    Fountain Valley, California, 92708, United States

  • Hospital General Universitario Gregorio Maranon

    Madrid, 28007, Spain

  • Hospital Universitario Puerta del Mar

    Cadiz, 11009, Spain

  • Hospital Universitario Virgen Nieves

    Granada, 18012, Spain

  • Hospital de Manises

    Manises, Valencia, 46940, Spain

  • Integrative Skin Science and Research

    Sacramento, California, 95815, United States

  • Klinika Ambroziak Dermatologia

    Warsaw, 02-953, Poland

  • Laser Rejuvenation Clinics Edmonton D.T. Inc

    Edmonton, Alberta, T5J 3S9, Canada

  • Mayo Clinic

    Scottsdale, Arizona, 85259, United States

  • Mayo Clinic Hospital

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic Specialty Building

    Phoenix, Arizona, 85054, United States

  • Medical Dermatology Specialists

    Phoenix, Arizona, 85006, United States

  • NMC Research LLC

    Tampa, Florida, 33607, United States

  • North York Research Inc

    Toronto, Ontario, M2N 3A6, Canada

  • Northridge Clinical Trials

    Northridge, California, 91325, United States

  • Olympian Clinical Research

    Largo, Florida, 33770, United States

  • Olympian Clinical Research

    Tampa, Florida, 33615, United States

  • Options Research Group

    West Lafayette, Indiana, 47906, United States

  • Palmetto Clinical Trial Services - Greenville

    Greenville, South Carolina, 29615, United States

  • Papageorgiou General Hospital of Thessaloniki

    Thessaloniki, Thessaloníki, 564 29, Greece

  • Państwowy Instytut Medyczny MSWiA

    Warsaw, 02-507, Poland

  • Penta Hospitals Badania Kliniczne sp. z o.o.

    Gdansk, 80-546, Poland

  • Revival Research Institute, LLC

    Southfield, Michigan, 48034, United States

  • Revival Research Institute, LLC

    Troy, Michigan, 48084, United States

  • Royalderm Agnieszka Nawrocka

    Warsaw, 02-962, Poland

  • Ryan Clinical Research Inc.

    Newmarket, Ontario, L3Y 5G8, Canada

  • Skin Care Research

    Boca Raton, Florida, 33486, United States

  • Skin Physicians Dermatology

    Edmonton, Alberta, T6W 4V4, Canada

  • Skin Specialists, PC dba Schlessinger MD

    Omaha, Nebraska, 68144, United States

  • Skin and Hair Center

    Overland Park, Kansas, 66213, United States

  • Soft Skin Medical Center Dr Elzbieta Wojtowicz-Prus

    Wroclaw, 50-551, Poland

  • Stracskin

    Portsmouth, New Hampshire, 03801, United States

  • The Indiana Clinical Trials Center, PC

    Plainfield, Indiana, 46168, United States

  • Trialmed CRS - Warszawa

    Warsaw, 02-482, Poland

  • TruDerm & TruSpa

    Wellington, Florida, 33449, United States

  • Twoja Przychodnia Szczecinskie Centrum Medyczne Sp. z o.o.

    Szczecin, 71-500, Poland

  • USF Florida Hearing Clinic

    Tampa, Florida, 33620, United States

  • USF Health

    Tampa, Florida, 33612, United States

  • Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden

    Dresden, Saxony, 01307, Germany

  • University General Hospital of Larissa

    Larissa, Thessalía, 411 10, Greece

  • Universitätsklinikum Frankfurt

    Frankfurt, 60590, Germany

  • Universitätsklinikum Schleswig Holstein - Campus Lübeck

    Lübeck, 23538, Germany

  • Uniwersytecki Szpital kliniczny im. F. Chopina w Rzeszowie

    Rzeszów, 35-055, Poland

  • Wolverine Clinical Trials

    Santa Ana, California, 92706, United States

  • Ziaderm Research LLC

    North Miami Beach, Florida, 33162, United States

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