New study aims to predict breathing problems in tiniest preemies
NCT ID NCT07186790
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study will observe 160 very premature babies (born before 32 weeks and weighing under 1,500 grams) to find out why some fail non-invasive breathing support like CPAP. The goal is to identify risk factors that lead to needing a breathing tube. This is an observational study, so no new treatment is being tested, but the findings could help doctors make better decisions for these fragile infants.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors identify which preterm babies are at risk of breathing support failure, leading to earlier and better treatment decisions.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly test any new therapy. Results may not apply to all hospitals or populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 160 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2025
An estimate. Start dates often move.
- Expected to finish
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Oct 2025
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population will consist of preterms aged \<32 weeks and what is the risk factors for failure of non invasive ventilation that lead them to use invasive ventilation
- Ages
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1 day to 28 days
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: \- The study will include neonates who meet all of the following criteria: 1. Preterms born at a gestational age of less than 32 weeks. 2. Birth weight less than 1,500 grams (very low birth weight). 3. Received initial non-invasive ventilation (e.g., CPAP or HFNC) within the first hours of life. 4. Admitted to participating NICUs during the study period. 5. Complete medical records available for review and analysis. Exclusion Criteria: \- Preterms will be excluded from the study if they meet any of the following conditions: 1. Received immediate invasive mechanical ventilation at birth without a trial of non-invasive ventilation. 2. Presence of major congenital anomalies (e.g., congenital diaphragmatic hernia, significant cardiac malformations). 3. Diagnosed with chromosomal abnormalities or genetic syndromes. 4. Incomplete or missing medical records that prevent accurate data extraction. 5. Preterms transferred from another hospital after initiation of respiratory support.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.