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New drug shows promise in lung cancer trial

NCT ID NCT07288177

Disease control Sponsor: Genmab Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 27, 2026 · Updated 6 times

Summary

This study tests a new drug called Rina-S in about 240 people with advanced non-small cell lung cancer. The goal is to see if the drug can shrink tumors or slow cancer growth. All participants receive the active drug, and treatment may continue as long as it helps and side effects are manageable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 240 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: * Participant has histologically or cytologically confirmed metastatic or locally advanced NSCLC of adenocarcinoma histology, not amenable to curative surgery or radiotherapy. * Participant must have radiological disease progression while on or after receiving the most recent regimen. * Participants either may have actionable genetic alterations (AGAs) or no AGAs. * Participant has measurable disease according to RECIST v1.1. * Participant has an Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score of 0 or 1 within 7 days of Cycle 1 Day 1. Key Exclusion Criteria (all study cohorts): * Participant has NSCLC with histology other than adenocarcinoma * Participant has a past or current malignancy other than the inclusion diagnosis before the planned first dose of trial treatment, or any evidence of residual disease from a previously diagnosed malignancy. Exceptions are malignancies with a negligible risk of metastasis or death (eg, 5-year OS ≥ 90%), including, but not limited to, adequately treated cervical carcinoma of stage 1B or less, in situ basal cell or squamous cell skin carcinoma, in situ bladder cancer, ductal carcinoma in situ, or any past malignancy considered cured for ≥ 3 years. * Participants with newly identified or known unstable (eg, progressing brain metastases) or symptomatic central nervous system (CNS) metastases or history of carcinomatous meningitis (also known as leptomeningeal disease). Participants with history of spinal cord compression (from disease). Participants with previous CNS-directed therapy (eg, radiotherapy and/or surgery) for brain metastases may participate provided lesion(s) are radiologically stable (ie, without evidence of progression) for at least 28 days by repeat imaging. Note: Other protocol-defined Inclusion and Exclusion criteria may apply.

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

lung adenocarcinoma non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non-small cell lung cancer (NSCLC)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    74 sites in 13 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AZ Delta (Campus Wilgenstraat)

    RECRUITING

    Roeselare, Belgium

  • Assistance Publique Hôpitaux de Marseille - Hôpital Nord

    RECRUITING

    Marseille, France

  • Astera Cancer Care

    RECRUITING

    East Brunswick, New Jersey, 08816, United States

  • Baylor Charles A. Sammons Cancer Center

    RECRUITING

    Dallas, Texas, 75246, United States

  • Beijing Chest Tumor Hospital

    RECRUITING

    Beijing, China

  • Bács-Kiskun Megyei Kórház - Kecskemét

    RECRUITING

    Kecskemét, Hungary

  • Changhua Christian Hospital

    RECRUITING

    Changhua, Taiwan

  • Chi Mei Medical Center - Liouying

    RECRUITING

    Tainan, Taiwan

  • Chris O'Brien Lifehouse

    RECRUITING

    Camperdown, Australia

  • Chu Helora Hospital La Louvière Site Jolimont

    RECRUITING

    La Louvière, Belgium

  • Clinica Universidad de Navarra - Madrid

    RECRUITING

    Madrid, Spain

  • Clinica Universidad de Navarra - Pamplona

    RECRUITING

    Pamplona, Spain

  • Cochin Hospital

    RECRUITING

    Paris, France

  • Compassionate Cancer Care Center

    RECRUITING

    Fountain Valley, California, 92708, United States

  • Emory Winship Cancer Institute

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Evangelische Lungenklinik Berlin

    RECRUITING

    Berlin, Germany

  • Fundación IVO. Instituto Valenciano de Oncología

    RECRUITING

    Valencia, Spain

  • Gdański Uniwersytet Medyczny

    RECRUITING

    Gdansk, Poland

  • GenesisCare North Shore

    RECRUITING

    Saint Leonards, Australia

  • Groupe Hospitalier Paris Saint-Joseph

    RECRUITING

    Paris, France

  • Henan Cancer Hospital

    RECRUITING

    Zhengzhou, China

  • Hospital Clinico Universitario de Valencia

    RECRUITING

    Valencia, Spain

  • Hospital Germans Trias i Pujol

    RECRUITING

    Barcelona, Spain

  • Hospital Quirón Málaga

    RECRUITING

    Málaga, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, Spain

  • Icon Cancer Care - Townsville

    RECRUITING

    Hyde Park, Australia

  • Icon Cancer Centre Hobart

    RECRUITING

    Hobart, Australia

  • Institut Curie - Centre de Recherche

    RECRUITING

    Paris, France

  • Instytut MSF

    RECRUITING

    Lodz, Poland

  • Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)

    RECRUITING

    Meldola, Italy

  • Istituto di Candiolo - IRCCS

    RECRUITING

    Candiolo, Italy

  • Japan Community Health Care Organization Chukyo Hospital

    RECRUITING

    Nagoya, Minami Ward, Japan

  • KOMED Roman Karaszewski I Wspolnicy Spolka Jawna

    RECRUITING

    Krakow, Poland

  • Kaiser Permanente San Diego Mission Road

    RECRUITING

    San Diego, California, 92108, United States

  • Kanagawa Cardiovascular and Respiratory Center

    RECRUITING

    Yokohama, Kanagawa, Japan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    RECRUITING

    Kaohsiung City, Taiwan

  • Kitasato University Hospital

    RECRUITING

    Sagamihara, Kanagawa, Japan

  • Krankenhaus Martha-Maria Halle-Dölau

    RECRUITING

    Halle, Germany

  • Kyoto Prefectural University of Medicine

    RECRUITING

    Kyoto, Kyoto, Japan

  • Leids Universitair Medisch Centrum

    RECRUITING

    Leiden, Netherlands

  • Lyon Sud Hospital Center

    RECRUITING

    Pierre-Bénite, France

  • MD Anderson Cancer Center Madrid

    RECRUITING

    Madrid, Spain

  • MedPolonia

    RECRUITING

    Poznan, Poland

  • MedStar Georgetown University Hospital

    RECRUITING

    Washington D.C., District of Columbia, 20007, United States

  • Moffitt Cancer Center and Research Institute

    RECRUITING

    Tampa, Florida, 33612, United States

  • Montefiore Medical Park

    RECRUITING

    The Bronx, New York, 10461, United States

  • NHO Kinki Chuo Chest Medical Center

    RECRUITING

    Sakai, Osaka, Japan

  • National Cheng Kung University

    RECRUITING

    Tainan, Taiwan

  • Nebraska Hematology-Oncology

    RECRUITING

    Lincoln, Nebraska, 68506, United States

  • ONE Onc: New York Oncology Hematology

    RECRUITING

    Albany, New York, 12206, United States

  • Parc de Salut Mar - Hospital del Mar

    RECRUITING

    Barcelona, Spain

  • Providence Medical Foundation (St. Joseph Heritage Healthcare)

    RECRUITING

    Santa Rosa, California, 95403, United States

  • Providence Oncology & Hematology Care Clinic - Westside

    RECRUITING

    West Haven-Sylvan, Oregon, 97225, United States

  • Providence Portland Medical Center

    RECRUITING

    Portland, Oregon, 97213, United States

  • START Rioja

    RECRUITING

    Logroño, Spain

  • Saitama Medical University International Medical Center

    RECRUITING

    Saitama, Moroyama, Japan

  • Shanghai East Hospital

    RECRUITING

    Shanghai, Pudong, China

  • St Andrews Medical Centre

    RECRUITING

    Adelaide, Australia

  • St John of God Murdoch Hospital

    RECRUITING

    Murdoch, Australia

  • St. Vincent Frontier Cancer Center

    RECRUITING

    Billings, Montana, 59102, United States

  • Szent Borbála Hospital

    RECRUITING

    Tatabánya, Hungary

  • Taipei Medical University - Shuang Ho Hospital, Ministry of Health and Welfare

    RECRUITING

    New Taipei City, Taiwan

  • Tennessee Oncology - Nashville St. Thomas Midtown Clinic

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Tennessee Oncology Nashville - SCRI Oncology Partners

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • The First Affiliated Hospital of Hebei North University

    RECRUITING

    Zhangjiakou, China

  • The Netherlands Cancer Institute (NKI)

    RECRUITING

    Amsterdam, Netherlands

  • Tianjin Medical University Cancer Institute and Hospital

    RECRUITING

    Tianjin, China

  • Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital

    RECRUITING

    Tokyo, Japan

  • UNC Health - University of North Carolina

    RECRUITING

    Chapel Hill, North Carolina, 27514, United States

  • USP Instituto Universitario Dexeus

    RECRUITING

    Barcelona, Spain

  • UZ Leuven - Gasthuisberg Campus

    RECRUITING

    Leuven, Belgium

  • Universitaetsklinikum Essen

    RECRUITING

    Essen, Germany

  • Virginia Cancer Specialists

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Williamette Valley Cancer Institute and Research Center

    RECRUITING

    Eugene, Oregon, 97401, United States

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Other studies related to the condition(s) this trial covers.