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Tooth transplant breakthrough: new method aims to restore blood flow

NCT ID NCT05267249

Knowledge-focused Sponsor: Medical University of Graz Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at a new way to transplant mature teeth that might help them regain blood supply. Researchers reviewed the outcomes of 16 people who had this procedure. The goal was to see if the teeth survived and if blood flow returned.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
procedure
What this could lead to
If successful, this technique could improve the success rate of tooth transplants by helping them regain blood flow.
What could go wrong
This was a small, retrospective study with only 16 participants, so results may not apply to everyone. The technique is still new and needs more research.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

16 people

The number who actually took part.

Started

Aug 2021

Finished

Feb 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients who underwent Autotransplantation of mature teeth with simultaneous apicoectomy between July 2017 and July 2020

Ages

12 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and female consenting and judicious young people and adults * Written consent of the participant and, if applicable, of the legal guardian after education * Planned tooth transplantation with advanced or completed root growth Exclusion Criteria: * Contraindications for magnetic resonance imaging (MRI): (pronounced metal restorations, running orthodontics with metal, fixed appliance in the target jaw) * Current or past antiresorptive therapy with bisphosphonates * Further anamnestic general or local risk situation, among others: Anti-angiogenic therapy, History of local radiation therapy, severe coagulation disorder, unadjusted diabetes mellitus, malignant diseases * Acute gingivitis or advanced periodontitis * Participation in an ongoing drug trial (various drugs may distort the result, such as bisphosphonates, cortisone, chemotherapeutics, angiogenesis inhibitors) * heavy smokers (\> 10 per day) * Acute or chronic infections (osteomyelitis) at the surgical site * metabolic diseases (diabetes, hyperparathyroidism, osteomalacia) * Severe kidney dysfunction, severe liver disease * Patients with high-dose corticosteroid therapy * prolonged corticosteroid or radiotherapy in the oral cavity * autoimmune diseases * Pregnant or breastfeeding women

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Conditions

The condition(s) this trial relates to.

dental pulp calcification dental pulp disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endodontic disease Pulp canal obliteration

Contacts and locations

Locations

  • Medical University of Graz

    Graz, Styria, 8010, Austria

More trials for these conditions

Other studies related to the condition(s) this trial covers.