New Sound-Based device could revolutionize fluid management in surgery
NCT ID NCT07516470
First seen Jun 24, 2026 · Last updated Jul 17, 2026 · Updated 4 times
Summary
This trial tests a new device called ResQ that listens to heart and lung sounds through a soft probe in the esophagus to predict if a patient needs more fluids during surgery. Researchers will compare its accuracy to the standard method using an arterial line. The study involves 122 adults undergoing major abdominal or pelvic surgery under general anesthesia.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ResQ device (acoustic variability index monitor)
- What this could lead to
- If successful, this could provide a less invasive way to guide fluid management during surgery, potentially reducing complications.
- What could go wrong
- This is a small, early-stage trial with only 122 participants, so results may not apply to all patients. The device may not be as accurate as standard methods.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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122 people
The number who actually took part.
- Started
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Apr 2026
- Finished
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Jul 2026
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of adult patients at Asan Medical Center in Seoul, South Korea. Participants will be recruited from the patients scheduled to undergo elective major surgeries involving organs in the abdominal, retroperitoneal, or pelvic cavities (such as hepatobiliary, pancreatic, intestinal, renal, or uterine procedures). These patients will be receiving general anesthesia and mechanical ventilation and are expected to require continuous intraoperative hemodynamic monitoring as part of their standard surgical care.
- Ages
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19 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: To participate in this study, individuals must meet all of the following criteria: * Adults aged 19 years or older. * If female, not pregnant or breastfeeding. * Scheduled for a planned surgery of major organs in the abdominal, retroperitoneal, or pelvic cavities (e.g., hepatobiliary and pancreatic, small intestine, large intestine, kidney, uterus) under general anesthesia with mechanical ventilation * Classified as American Society of Anesthesiologists (ASA) Class I, II, or III. (Note: Excluded regardless of class if any exclusion criteria are met) * Scheduled to receive mechanical ventilation in a volume-controlled or pressure-controlled mode in the operating room or intensive care unit, with an anticipated tidal volume of 6-8 mL/kg (Ideal Body Weight), respiratory rate of 8-14 breaths/min, and PEEP of 0-5 cmH2O * Scheduled for hemodynamic monitoring to measure the comparison indices during surgery * Able to understand the study's purpose and procedures and communicate clearly with the investigator and research staff * Voluntarily signed the written informed consent form before participating in the study Exclusion Criteria: Individuals meeting any of the following criteria will be excluded from participation: * Undergoing emergency or unplanned surgery * Anticipated to have difficulty with the application of general anesthesia or mechanical ventilation * Anticipated to experience massive bleeding of 1 L or more during surgery. * Undergoing a reoperation due to the same underlying disease * History of severe esophageal damage (e.g., esophageal varices or stricture) that makes inserting the probe difficult * Inability to have an arterial catheter inserted, making the measurement of Stroke Volume Variation (SVV) and Pulse Pressure Variation (PPV) difficult * Condition where a fluid challenge is contraindicated or considered high risk (e.g., clinical signs of fluid overload, pulmonary congestion, or pulmonary edema; acute exacerbation of heart failure or renal failure; or a hemodynamically unstable state) * Body Mass Index (BMI) greater than 30 kg/m² * Uncontrolled coagulopathy prior to surgery (e.g., Platelet count \< 100,000/μL or INR \> 2) * Arrhythmias, such as atrial fibrillation/flutter or premature atrial/ventricular contractions (\>2 per 10 seconds), that make it difficult for the variability index to operate accurately * Other cardiovascular history that makes accurate cardiac output measurement impossible (e.g., severe valvular disease, history of intracardiac shunt surgery, or structural heart surgery) * Pregnant or lactating women * Any other condition deemed unsuitable for study participation by the investigator
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Asan Medical Center
Seoul, Seoul, 05505, South Korea
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