Allergy test length may fuel gut bacteria resistance in children
NCT ID NCT04062344
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looked at children aged 0-18 who had mild, delayed allergic reactions to beta-lactam antibiotics (like amoxicillin). Researchers compared short (1-4 days) and long (5-8 days) oral drug challenge tests to see if longer testing increased the growth of antibiotic-resistant bacteria in the gut. Rectal swabs were taken before and after the test to check for resistant germs. The goal was to understand if longer testing poses a hidden risk of promoting superbugs.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors choose safer testing durations for children with suspected beta-lactam allergies, reducing the risk of antibiotic resistance.
- What could go wrong
- This is a small, completed observational study with only 50 participants. It does not test a treatment, so it cannot directly change clinical practice without further research.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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50 people
The number who actually took part.
- Started
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Mar 2021
- Finished
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Jan 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Minors in consultation at Necker Hospital
- Ages
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0 to 17 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria : * Minors aged 0 to 18 * Consultation in Necker for an oral drug provocation test to explore mild (urticaria, edema, maculo-papulous exanthema) delayed-onset reaction (1 hour after initiation of treatment) to betalactams (amoxicillin +/-clavulanic acid, cefpodoxime, cefixime, cefuroxime) Exclusion Criteria : * Minors with potentially severe delayed-onset reactions (painful skin lesions, atypical target lesions, erosions of mucosa, centro facial oedema, purpuric infiltrated papules) or severe (Lyell/Stevens Johnson Syndrome, fixed drug eruption, acute generalized exanthematous pustulosis, skin rash with systemic and hypereosinophilic disorders) * Antibiotic treatment within the past month before the drug provocation test * Travel abroad within the past 6 months before the drug provocation test * Cardio-respiratory failure, renal failure, hepatic impairment or any other severe chronic pathology
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Necker-Enfants Malades
Paris, Paris, 75015, France