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Cure My Disease

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Could a new shot clear Alzheimer's brain plaques? major trial results are in!

NCT ID NCT05463731

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This large Phase 3 study tested an experimental drug called remternetug in over 1,600 people with early symptoms of Alzheimer's disease. The main goal was to see if the drug could safely clear amyloid plaques from the brain, a hallmark of Alzheimer's. Participants received either the drug or a placebo, and researchers measured plaque levels using brain scans.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

1,667 people

The number who actually took part.

Started

Aug 2022

Finished

May 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Gradual and progressive change in cognitive function ≥6 months prior to screening. * A Mini-Mental (MMSE) score of 20 to 30 (inclusive) at screening. * Has an amyloid PET scan result consistent with the eligibility criteria. * Have a reliable study partner who will provide written informed consent to participate and is in frequent contact with the participant. * Have adequate literacy, vision, and hearing for the neuropsychological testing in the opinion of the investigator at the time of screening. * Are reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures. * Males and females will be eligible for this study. * Women not of childbearing potential (WNOCBP) may participate in this trial. Exclusion Criteria: * Current serious or unstable illnesses that, in the investigator's opinion, could interfere with the analyses in this study; or has a life expectancy of \<24 months. * History of cancer with high risk of recurrence and preventing completion of the trial. * Participants with any current primary psychiatric diagnosis other than AD that in the investigator's opinion, is likely to confound interpretation of the drug effect, affect cognitive assessment, or affect the participant's ability to complete the study. * History of clinically significant multiple or severe drug allergies. * Have any clinically important abnormality at screening, as determined by investigator that could be detrimental to the participant, could compromise the study, or show evidence of other etiologies for dementia. * Screening magnetic resonance imaging (MRI) which shows evidence of significant abnormality that would suggest another potential etiology for progressive dementia or a clinically significant finding that may impact the participant's ability to safely participate in the study. * Have any contraindications for MRI or positron emission tomography (PET). * Have had prior treatment with a passive anti-amyloid immunotherapy. * Have received active immunization against Aβ in any other study. * Have known allergies to remternetug related compounds, or any components of the formulation.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction dementia Plaque, Amyloid

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer's disease

Contacts and locations

Locations

  • AMC Research

    Matthews, North Carolina, 28105, United States

  • AMITA Health - Alexian Brothers Neurosciences Institute Clinical Research

    Elk Grove Village, Illinois, 60007, United States

  • Adams Clinical

    Watertown, Massachusetts, 02472, United States

  • Advanced Memory Research Institute of New Jersey

    Toms River, New Jersey, 08755, United States

  • Alpine Clinical Research Center

    Boulder, Colorado, 80301, United States

  • Alzheimer's Research and Treatment Center

    Stuart, Florida, 34997, United States

  • Alzheimer's Research and Treatment Center

    Wellington, Florida, 33414, United States

  • Anderson Clinical Research

    Redlands, California, 92374, United States

  • Brain Matters Research

    Delray Beach, Florida, 33445, United States

  • Brain Matters Research

    Stuart, Florida, 34997, United States

  • Care Access - Lake Charles

    Lake Charles, Louisiana, 70601, United States

  • Carteret Medical Group

    Morehead City, North Carolina, 28557, United States

  • Center for Cognitive Health

    Portland, Oregon, 97225, United States

  • Central Texas Neurology Consultants

    Round Rock, Texas, 78681, United States

  • Charter Research - Lady Lake

    The Villages, Florida, 32162, United States

  • Charter Research - Winter Park

    Orlando, Florida, 32803, United States

  • Citizens Memorial Hospital District

    Bolivar, Missouri, 65613, United States

  • ClinCloud - Maitland

    Maitland, Florida, 32751, United States

  • ClinCloud - Viera

    Melbourne, Florida, 32940, United States

  • Clinical Research Professionals

    Chesterfield, Missouri, 63005, United States

  • Colorado Springs Neurological Associates

    Colorado Springs, Colorado, 80907, United States

  • Columbus Memory Center, PC

    Columbus, Georgia, 31909, United States

  • Conquest Research

    Winter Park, Florida, 32789, United States

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231, United States

  • Cotton O'Neil Clinical Research Center - Central Office

    Topeka, Kansas, 66606, United States

  • Covenant Medical Center

    Waterloo, Iowa, 50702, United States

  • Emerald Coast Neurology - Airport Boulevard

    Pensacola, Florida, 32504, United States

  • Encore Research Group- Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216, United States

  • Finlay Medical Research

    Greenacres City, Florida, 33467, United States

  • Gadolin Research

    Beaumont, Texas, 77702, United States

  • Great Lakes Clinical Trials - Andersonville

    Chicago, Illinois, 60640, United States

  • Hope Clinical Research, Inc.

    Canoga Park, California, 91303, United States

  • Institute for Neurodegenerative Disorders

    New Haven, Connecticut, 06510, United States

  • Irvine Clinical Research

    Irvine, California, 92614, United States

  • JEM Research Institute

    Atlantis, Florida, 33462, United States

  • K2 Medical Research

    Maitland, Florida, 32751, United States

  • Kaizen Brain Center

    La Jolla, California, 92037, United States

  • Katayama Medical Clinic

    Kurashiki, Okayama-ken, 710-0813, Japan

  • Kerwin Medical Center

    Dallas, Texas, 75231, United States

  • Keystone Clinical Studies

    Plymouth Meeting, Pennsylvania, 19462, United States

  • Ki Health Partners, LLc, dba New England Institute for Clinical Research

    Stamford, Connecticut, 06905, United States

  • Las Vegas Medical Research

    Las Vegas, Nevada, 89128, United States

  • MD First Research - Chandler

    Chandler, Arizona, 85286, United States

  • MedVadis Research Corporation

    Waltham, Massachusetts, 02451, United States

  • Memory Clinic Ochanomizu

    Bunkyo-ku, Tokyo, 113-0034, Japan

  • Memory Clinic Toride

    Toride, Ibaraki, 302-0004, Japan

  • Merritt Island Medical Research, LLC

    Merritt Island, Florida, 32952, United States

  • Mountain Neurological Research Center

    Basalt, Colorado, 81621, United States

  • National Clinical Research, Inc

    Richmond, Virginia, 23294, United States

  • Neuro-Pain Medical Center

    Fresno, California, 93710, United States

  • NeuroScience Research Center

    Canton, Ohio, 44718, United States

  • Neurological Associates Albany

    Albany, New York, 12208, United States

  • Neurology Clinic, P.C.

    Cordova, Tennessee, 38018, United States

  • Neurology Consultants of Dallas, PA

    Dallas, Texas, 75243, United States

  • Neurology Diagnostics, Inc.

    Dayton, Ohio, 45459, United States

  • Neuropsychiatric Research Center of Southwest Florida

    Fort Myers, Florida, 33912, United States

  • North County Neurology Associates

    Carlsbad, California, 92011, United States

  • Northwest Clinical Research Center

    Bellevue, Washington, 98007, United States

  • Optimus U Corporation

    Miami, Florida, 33135, United States

  • Palm Beach Neurology

    West Palm Beach, Florida, 33407, United States

  • Progressive Medical Research

    Port Orange, Florida, 32127, United States

  • Re:Cognition Health

    Fairfax, Virginia, 22031, United States

  • Renstar Medical Research

    Ocala, Florida, 34470, United States

  • Rhode Island Mood & Memory Research Institute

    East Providence, Rhode Island, 02914, United States

  • Suncoast Clinical Research, Inc.

    New Port Richey, Florida, 34652, United States

  • Tallahassee Neurological Clinic

    Tallahassee, Florida, 32308, United States

  • Texas Diabetes & Endocrinology, P.A.

    Austin, Texas, 78749, United States

  • The Clinical Trial Center, LLC

    Jenkintown, Pennsylvania, 19046, United States

  • The Cognitive and Research Center of New Jersey

    Springfield, New Jersey, 07081, United States

  • The University of Texas Health Science Center at Houston

    Houston, Texas, 77054, United States

  • Universal Research Group

    Tacoma, Washington, 98405, United States

  • VIN-Andrew Lerman

    Miami, Florida, 33133, United States

  • VIN-Julie Schwartzbard

    Aventura, Florida, 33180, United States

  • Valley Medical Research

    Centerville, Ohio, 45459, United States

  • Wr- Pri, Llc

    Encino, California, 91316, United States

  • iResearch Atlanta

    Decatur, Georgia, 30030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.