Could a shot of your own blood ease menopause symptoms?
NCT ID NCT07306611
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether injecting platelet-rich plasma (PRP) from a woman's own blood into the vulvovaginal area can relieve symptoms of genital atrophy like dryness, burning, and pain during sex. It includes 30 women who cannot use standard hormone treatments. Half receive PRP and half receive a placebo, with follow-ups over six months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- platelet-rich plasma (PRP) injection
- What this could lead to
- If it works, this could offer a natural, hormone-free option to relieve symptoms of genital atrophy, especially for women who cannot use estrogen creams.
- What could go wrong
- This is a small early-phase trial with only 30 participants. PRP is still experimental for this condition, and the placebo group may show similar results. Long-term benefits are not yet known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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30 people
The number who actually took part.
- Started
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Jun 2024
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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25 to 80 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * At least one clinical complaint of VVA. * Dryness * Burning * Itching * Discomfort (soreness, irritation) * Dyspareunia (sexual impaired function) * With or without urinary problems (incontinence, urgency, dysuria). Must report a contra-indication with the standard local hormonal treatment. * Allergy * Burden side effects * Non-improvement with standard treatment * Hormonal cancer survivors must be in remission for two years after the last oncologic treatment. * Thrombotic disease patients must have the disease controlled and have passed 2 years after the thrombotic event. Must have a cervicovaginal cytology confirming the atrophy, having ≤ 5% of superficial cells on vaginal smear. Moreover, a normal morphologic cytology besides the inflammatory or atrophy change is mandatory. Must have a vaginal pH above 5 at baseline. Must have a normal mammography (American College of Radiology BI-RADS 1 or 2) within 12 months of study starts (Day 1), and normal breast examination. Willing to participate in the study and sign an informed consent. Exclusion Criteria: * Life expectancy \< 6 months due to concomitant illnesses. * Exposure to any investigational drug or procedure within 1 month prior to study entry or enrolled in a concurrent study that may confound results of this study. * Active infectious disease. Patients known to have tested positive for HIV, HTLV, HBV, HCV, CMV (IgM \> IgG) and/or syphilis will have an expert consultation as to patient eligibility based on the patient's infectious status. * Any illness which, in the Investigator's judgment, will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results. * Patients on chronic immunosuppressive transplant therapy. * Known drug or alcohol dependence or any other factors which will interfere with the study conduct or interpretation of the results or who in the opinion of the investigator are not suitable to participate. * Used oral, transdermal, vaginal, intrauterine, implants/injectables drugs that contained either oestrogens, progestins, androgens, or selective oestrogen receptor modulators (SERMs) before the study (a washout period of 4 weeks is required). Use of prescription and non-prescription medications and remedies known to alleviate VVA, discomfort including vaginal lubricants and moisturizers, are allowed during the study. * Any allergic reaction to local anaesthetics. * Unwilling and/or not able to give written informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Santo André Hospital
Leiria, Leiria District, 2410-197, Portugal
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