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New toothpaste may stop whitening pain

NCT ID NCT07506850

Symptom relief Sponsor: Universidade Federal do Para Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether special pastes containing CPP-ACP and fluoride could reduce tooth sensitivity after in-office bleaching. 64 adults received either a paste with CPP-ACP and sodium fluoride, CPP-ACP and stannous fluoride, or a placebo before and after whitening. Pain was measured over 72 hours. The goal is to find a way to make whitening more comfortable without reducing its effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CPP-ACP combined with sodium fluoride or stannous fluoride paste
What this could lead to
If it works, dentists may have a proven way to reduce pain after teeth whitening, making the procedure more comfortable.
What could go wrong
This is a small, completed trial with 64 people, so results may not apply to everyone. The pastes might not reduce sensitivity better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

Feb 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 years or older, of both sexes * Good general and oral health * Upper right canine classified as shade A2 or darker, according to the Vita Classical scale (VITA Zahnfabrik, Bad Säckingen, Germany) Exclusion Criteria: * Presence of active caries or periodontal disease * Visible cracks in upper or lower anterior teeth * Evident malocclusion * Restorations or prostheses in anterior teeth * Gastroesophageal disorders * Severe intrinsic tooth discoloration (e.g., tetracycline staining, fluorosis, or non-vital teeth) * Dentin exposure in anterior and/or posterior teeth * Parafunctional habits * Tooth sensitivity * Previous tooth bleaching or orthodontic treatment * Pregnant or lactating women * Individuals with allergies or sensitivities to milk protein or hydroxybenzoate-based preservatives

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Conditions

The condition(s) this trial relates to.

dentin sensitivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tooth sensitivity

Contacts and locations

Locations

  • Universidade Federal do Pará

    Belém, Pará, 66075-110, Brazil

More trials for these conditions

Other studies related to the condition(s) this trial covers.