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New anesthesia combo could slash opioid use after hernia surgery

NCT ID NCT05953428

Symptom relief Sponsor: Endeavor Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study tested whether a special anesthesia plan using dexmedetomidine and ketamine could reduce the need for opioid painkillers after laparoscopic hiatal hernia repair. Fifty adults having elective surgery were randomly assigned to receive either the opioid-sparing protocol or standard opioid-based anesthesia. The goal was to see if the new approach lowers opioid use at discharge and during recovery, while also tracking pain scores, nausea, and hospital costs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Opioid Sparing Anesthesia Protocol (dexmedetomidine and ketamine)
What this could lead to
If successful, this could offer a way to manage pain after hiatal hernia surgery with fewer opioids, reducing the risk of addiction and side effects.
What could go wrong
This is a small, early-phase study with only 50 participants, so results may not apply to everyone. The non-opioid drugs also have their own side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Mar 2024

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients from 18-90 years old who are undergoing laparoscopic hiatal hernia surgery * Elective Laparoscopic hiatal hernia repair Exclusion Criteria: * Patients receiving urgent or emergent hiatal hernia surgery * Patients receiving hiatal hernia surgery without laparoscopy * Patients with adverse reactions (e.g., anaphylaxis, rash) to any of the drugs in the OBA or OSA protocols.

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Conditions

The condition(s) this trial relates to.

hiatus hernia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hiatal hernia

Contacts and locations

Locations

  • Endeavor Health

    Evanston, Illinois, 60201, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.