Can a steroid or a sedative stop the pain when the numbness wears off?
NCT ID NCT07299877
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding dexamethasone (a steroid), dexmedetomidine (a sedative), or both to standard numbing medicine can prevent the intense pain that often occurs when a nerve block wears off after arm surgery. About 75 adults having elective upper limb surgery will be randomly assigned to one of three groups. The main goal is to see how many people experience rebound pain and how severe it is.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- dexamethasone and/or dexmedetomidine added to local anesthetics (lidocaine and bupivacaine)
- What this could lead to
- If successful, this could point to a simple way to prevent severe pain after nerve blocks wear off, improving recovery for arm surgery patients.
- What could go wrong
- This is a small, early-phase trial with only 75 participants, so results may not apply to everyone. The drugs may not reduce rebound pain as hoped, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 75 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * from 20-65 years old * and ASA physical status I or II and III, * and of either gender, * who provided informed, written, and valid consent, * were scheduled for elective orthopedic upper limb surgeries for traumatic fractures under Supraclavicular Brachial Plexus Block. Exclusion Criteria: * Patients with coagulopathies, * neurological disorders, * hypersensitivity to any of the study drugs, or * a history of previous surgeries on the affected limb * and those who refused to sign informed consent
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Benha University, Faculty of Medicine
Banhā, Qalyubiyya, 300001, Egypt
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