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New study tests simple trick to stop pain after nerve block wears off

NCT ID NCT07666971

Symptom relief Sponsor: Centre Hospitalier Universitaire Vaudois Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether giving scheduled morphine doses alongside on-demand pain relief can prevent the severe 'rebound pain' that often occurs when a nerve block wears off after orthopedic surgery. One hundred adults having arm or leg surgery will be randomly assigned to receive either on-demand morphine alone or on-demand plus scheduled slow-release morphine. The main goal is to see which group reports less worst pain in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Morphine (oral, immediate-release and slow-release)
What this could lead to
If successful, this could provide a simple way to prevent severe rebound pain after surgery, reducing the need for extra painkillers and improving recovery.
What could go wrong
This is a small, early-stage trial with only 100 participants. The results may not apply to all surgeries or patients, and adding scheduled morphine could increase side effects like nausea or drowsiness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for elective orthopaedic surgery on the upper limb * Patients scheduled for elective orthopaedic surgery on the lower limb. * Score ASA I-III; Patients aged over 18 years; Signed informed consent. * Surgery under general anaesthesia or under sedation Exclusion Criteria: * Refusal or inability to understand the informed consent * Allergy to any of the following medications: ropivacaine, paracetamol, ibuprofen, ketorolac, morphine,sufentanil, ondansetron, or dexamethasone * Patients with long term opioid treatment * Bleeding diathesis * Neurological disorders of the operated limb * Known renal insufficiency (eGFR \<30 mL/min) * Known hepatic insufficiency (Child-Pugh class B or C); * Pregnant or breastfeeding women; * Alcohol dependence syndrome; * Patients under spinal anaesthesia; * Patients undergoing amputation procedures

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Conditions

The condition(s) this trial relates to.

agnosia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post operative analgesia Post operative pain, acute Rebound pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHUV, Centre Hospitalier Vaudois

    Lausanne, 1000, Switzerland

More trials for these conditions

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