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Which drug stops rebound pain better? new study tests two options

NCT ID NCT06304909

Symptom relief Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 111 people having arm surgery to see if a drug called dexmedetomidine or dexamethasone could prevent severe pain when the numbing shot wears off. Participants got one of the two drugs or a saltwater placebo. The goal was to see which drug reduces the chance of sudden, intense pain 12 to 24 hours after the block.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine and dexamethasone
What this could lead to
If one drug works better, it could give doctors a simple way to prevent severe pain after a nerve block wears off.
What could go wrong
This is a small, early-phase study (Phase 1) with only 111 people. Results may not apply to everyone, and the drugs may not show a clear difference.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

111 people

The number who actually took part.

Started

May 2024

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients between 20\_60 years old * Patients with ASA clinical status I/II * Patients scheduled for peripheral nerve block for upper extremity surgery Exclusion Criteria: * 1\) they refused to participate 2) had preexisting neuropathy of the surgical limb 3) hypersensitivity to amide anesthetic 4) significant pulmonary disease 5) coagulopathy 6) sepsis 7) infection at the block site 8) hypersensitivity to dexmedetomidine \& dexamethasone

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Conditions

The condition(s) this trial relates to.

Accidental Injuries injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Trauma injury

Contacts and locations

Locations

  • Marwa Mahmoud Rady

    Asyut, Assiut Governorate, 1987, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.