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New lung cancer pill takes on chemo in major trial

NCT ID NCT06881784

Disease control Sponsor: Revolution Medicines, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 8 times

Summary

This Phase 3 trial is testing a new oral drug called daraxonrasib (RMC-6236) against the standard chemotherapy docetaxel in about 590 people with advanced non-small cell lung cancer that has a specific RAS mutation. Participants must have already tried at least one prior treatment including immunotherapy and platinum chemo. The study aims to see if the new drug can delay cancer growth and improve survival better than chemo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
daraxonrasib (RMC-6236)
What this could lead to
If it works, this could offer a new targeted treatment option for people with a specific type of advanced lung cancer that has stopped responding to standard therapies.
What could go wrong
This is an early-stage Phase 3 trial, so results are not yet known. The new drug may not prove more effective than docetaxel and could have unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 590 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * At least 18 years old and has provided informed consent. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Pathologically confirmed NSCLC, either locally advanced or metastatic, not amenable to curative surgery or radiotherapy. * Measurable disease per RECIST v1.1. * Adequate organ function (bone marrow, liver, kidney, coagulation). * One to two prior lines of therapy including an anti-PD-1/anti-PD(L)-1 agent and platinum-based chemotherapy. * Documented RAS mutation status, defined as Nonsynonymous mutations in KRAS, NRAS, or HRAS at codons 12, 13, or 61 (G12, G13, or Q61). * Able to take oral medications. Exclusion Criteria: * Prior therapy with direct RAS-targeted therapy or docetaxel. * Untreated central nervous system (CNS) metastases. * Medically significant comorbidities (significant cardiovascular disease, lung disease, or impaired GI function). * Ongoing anticancer therapy. * Pregnant or breastfeeding.

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non-small cell lung cancer NSCLC NSCLC (advanced non-small cell lung cancer) NSCLC (non-small cell lung cancer) NSCLC (non-small cell lung carcinoma)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    153 sites in 19 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • AZ Delta

    RECRUITING

    Roeselare, 8800, Belgium

  • AZ Groeninge

    RECRUITING

    Kortrijk, 8500, Belgium

  • Aichi Cancer Center Hospital

    RECRUITING

    Nagoya, Aichi-ken, 464-8681, Japan

  • Aidport Sp. z o.o.

    RECRUITING

    Skorzewo, 60-185, Poland

  • Ajou University Hospital

    RECRUITING

    Gyeonggi-do, Suwon-si, 16499, South Korea

  • Alabama Oncology

    RECRUITING

    Birmingham, Alabama, 35243, United States

  • Alfred House

    RECRUITING

    Melbourne, Victoria, 3004, Australia

  • Amsterdam UMC, Locatie VUMC

    RECRUITING

    Amsterdam, Netherlands, 1081BT, Netherlands

  • Antoni van Leeuwenhoek

    RECRUITING

    Amsterdam, 1066 CX, Netherlands

  • Auckland City Hospital - Cancer and Blood Research

    RECRUITING

    Grafton, Auckland, 1023, New Zealand

  • Avera Cancer Institute

    RECRUITING

    Sioux Falls, South Dakota, 57105, United States

    Contact Email: •••••@•••••

  • Avera Saint Luke's Hospital

    RECRUITING

    Aberdeen, South Dakota, 57401, United States

    Contact Email: •••••@•••••

  • Azienda Ospedaliero Universitaria Pisana (Presidio di Cisanello)

    RECRUITING

    Pisa, Pisa, 56124, Italy

  • Azienda Socio Sanitaria Territoriale Niguarda

    RECRUITING

    Milan, Milano, 21206, Italy

  • BRCR Global

    RECRUITING

    Plantation, Florida, 33322, United States

  • Beaumont Hospital Cancer Clinical

    RECRUITING

    Dublin, D09 V2N0, Ireland

  • Blacktown Medical Oncology Research

    RECRUITING

    Blacktown, New South Wales, 2148, Australia

  • Blacktown Medical Oncology Research, Blacktown Hospital

    RECRUITING

    Blacktown, New South Wales, 2148, Australia

  • CHU Brest - Hôpital Morvan

    RECRUITING

    Brest, 29200, France

  • CHU Nantes - Hôpital Guillaume et René Laënnec

    RECRUITING

    Saint-Herblain, Loire Atlantique, 44805, France

  • CHU Rennes Hôpital Pontchaillou

    RECRUITING

    Rennes, Ille et Vilaine, 35033, France

  • CHU Strasbourg - Nouvel Hôpital Civil

    RECRUITING

    Strasbourg, Bas Rhin, 67091, France

  • CHU de Grenoble - Hôpital Albert Michallon

    RECRUITING

    La Tronche, Isere, 38700, France

  • CHU de Toulouse - Hopital Larrey

    RECRUITING

    Toulouse, 31059, France

  • Calvary Mater Newcastle

    RECRUITING

    Waratah, New South Wales, 2298, Australia

  • Cancer Care Centers of Breevard

    RECRUITING

    Rockledge, Florida, 32955, United States

  • Cancer Institute Hospital of JFCR

    RECRUITING

    Koto-Ku, Tokyo, 135-8550, Japan

  • Center for Care and Discovery

    RECRUITING

    Chicago, Illinois, 60637, United States

    Contact Email: •••••@•••••

  • Centre Hospitalier Intercommunal de Créteil

    RECRUITING

    Créteil, Val de Marne, 94000, France

  • Centre Leon Berard

    RECRUITING

    Léon, Lyon, 69008, France

  • Chang Gung Medical Foundation Linkou

    RECRUITING

    Taoyuan, 333, Taiwan

  • Chonnam National University Hwasun Hospital

    RECRUITING

    Hwasun, 58128, South Korea

  • Chris O'Brien Lifehouse

    RECRUITING

    Camperdown, New South Wales, 2050, Australia

  • Chungbuk National University Hospital

    RECRUITING

    Cheongju-si, 28644, South Korea

  • Cleveland Clinic Martin North

    RECRUITING

    Stuart, Florida, 34994, United States

  • Complejo Hospitalario Universitario A Coruña

    RECRUITING

    A Coruña, A Coruña, 15006, Spain

  • Cork Univeristy Hospital

    RECRUITING

    Cork, Cork, T12 DC4A, Ireland

  • Dartmouth-Hitchcock Medical Center

    RECRUITING

    Lebanon, New Hampshire, 03756, United States

  • Erasmus Medisch Centrum

    RECRUITING

    Rotterdam, Netherlands, 3015AA, Netherlands

  • Evangelische Lungenklinik Berlin

    RECRUITING

    Berlin, 13125, Germany

  • Florida Cancer Specialists & Research Institute - East

    RECRUITING

    West Palm Beach, Florida, 33401, United States

    Contact Email: •••••@•••••

  • Florida Cancer Specialists & Research Institute - North

    RECRUITING

    St. Petersburg, Florida, 33705, United States

    Contact Email: •••••@•••••

  • Florida Cancer Specialists & Research Institute - South

    RECRUITING

    Fort Myers, Florida, 33901, United States

    Contact Email: •••••@•••••

  • Fondazione IRCCS San Gerardo dei Tintori

    RECRUITING

    Monza, Milan, 20900, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    RECRUITING

    Rome, 00168, Italy

  • Fujita Health University Hospital

    RECRUITING

    Toyoake-shi, Aichi-ken, 470-1192, Japan

  • Galway University Hospital

    RECRUITING

    Galway, H91 YR71, Ireland

  • Grand Hôpital de Charleroi - Les Viviers

    RECRUITING

    Gilly, 6060, Belgium

  • HFR Fribourg/Kantonsspital Fribourg

    RECRUITING

    Fribourg, 1708, Switzerland

  • Henry Ford Health

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Hong Kong United Oncology Centre

    RECRUITING

    Hong Kong, Hong Kong

    Contact Email: •••••@•••••

  • Hopital Albert Calmette - CHU Lille

    RECRUITING

    Lille, Nord, 59037, France

  • Hopital Louis Pradel

    RECRUITING

    Bron, Rhone, 69677, France

  • Hopital Nord - CHU Marseille

    RECRUITING

    Marseille, Bouches-du-Rhône, 13915, France

  • Hospital Universitari Dexeus

    RECRUITING

    Barcelona, Barcelona, 08028, Spain

  • Hospital Universitario HM Madrid Sanchinarro

    RECRUITING

    Madrid, Madrid, 28050, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Fuencarral-El Pardo, Madrid, 28046, Spain

  • Hospital de la Santa Creu i Sant Pau

    RECRUITING

    Barcelona, 08041, Spain

  • Huntsman Cancer Institute

    RECRUITING

    Salt Lake City, Utah, 84112, United States

  • Hyogo Cancer Center

    RECRUITING

    Akashi, Hyōgo, 673-8558, Japan

  • Hôpital Bichat - Claude Bernard

    RECRUITING

    Paris, Paris, 75018, France

  • IEO Istituto Europeo di Oncologia

    RECRUITING

    Milan, Milano, 20141, Italy

  • INSTYTUT GENETYKI I IMMMUNOLOGII GENIM sp. z o.o.

    RECRUITING

    Lublin, 29-609, Poland

  • Icon Cancer Centre

    RECRUITING

    Singapore, 574623, Singapore

  • Institut Bergonie

    RECRUITING

    Gironde, 33076, France

  • Institut Gustave Roussy

    RECRUITING

    Vaillant, Villejuif, 94800, France

  • Institut Jules Bordet

    RECRUITING

    Anderlecht, Belgium, 1070, Belgium

  • Institut de Cancerologie de l Ouest

    RECRUITING

    Saint-Herblain, Loire Atlantique, 44805, France

  • Institut régional du Cancer de Montpellier

    RECRUITING

    Montpellier, Herault, 34298, France

  • Istituto Clinico Humanitas

    RECRUITING

    Rossano, Milano, 20089, Italy

  • Istituto Nazionale Tumori Fondazione G. Pascale

    RECRUITING

    Naples, Napoli, 80131, Italy

  • Istituto Nazionale dei Tumori Regina Elena IRCCS

    RECRUITING

    Roma, Roma, 00144, Italy

  • John Theurer Cancer Center at Hackensack UMC

    RECRUITING

    Hackensack, New Jersey, 07601, United States

  • Johns Hopkins University of Medicine

    RECRUITING

    Baltimore, Maryland, 21224, United States

    Contact Email: •••••@•••••

  • Kanagawa Cancer Center

    RECRUITING

    Yokohama, Kanagawa, 241-8515, Japan

  • Kanazawa University Hospital

    RECRUITING

    Kanazawa, Ishikawa-ken, 920-8641, Japan

  • Kansai Medical University Hospital

    RECRUITING

    Hirakata-shi, Osaka, 573-1191, Japan

  • Kantonsspital St. Gallen

    RECRUITING

    Sankt Gallen, 9000, Switzerland

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    RECRUITING

    Kaohsiung, Taiwan, 100, Taiwan

  • Karmanos Cancer Institute

    RECRUITING

    Detroit, Michigan, 48201, United States

  • Kindai University Hospital

    RECRUITING

    Osakasayama-shi, Osaka, 589-8511, Japan

  • Klinika Onkologii I Radioterapii UCK

    RECRUITING

    Gdansk, 80-214, Poland

  • Klinikum Esslingen GmbH

    RECRUITING

    Baden, 73730, Germany

  • Korea University Anam Hospital

    RECRUITING

    Seoul, 02841, South Korea

  • LKI Lungenfachklinik Immenhausen

    RECRUITING

    Immenhausen, Hesse, 34376, Germany

  • MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Maastricht University Medical Center P. Debyelaan 25

    RECRUITING

    Maastricht, 6229, Netherlands

  • Mater Misericordiae Limited

    RECRUITING

    South Brisbane, Queensland, 4101, Australia

    Contact Email: •••••@•••••

  • Mater Private Hospital

    RECRUITING

    Dublin, Dublin, 7, Ireland

  • Med-Polonia Sp. z o.o.

    RECRUITING

    Poznan, 60-693, Poland

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • MemorialCare Long Beach Medical Center

    RECRUITING

    Long Beach, California, 90806, United States

  • Montefiore Medical Center

    RECRUITING

    The Bronx, New York, 10461, United States

  • Morristown Medical Center (MMCORC)

    RECRUITING

    Morristown, New Jersey, 07960, United States

  • NHO Himeji Medical Center

    RECRUITING

    Matsuyama, Ehime, 791-0280, Japan

  • NHO Shikoku Cancer Center

    RECRUITING

    Matsuyama, Ehime, 791-0280, Japan

  • Nara Medical University Hospital

    RECRUITING

    Kashihara-shi, Nara, 634-8522, Japan

  • National Cancer Center Hospital

    RECRUITING

    Chuo Ku, Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East

    RECRUITING

    Kashiwa-shi, Chiba, 277-8577, Japan

  • National Cancer Centre Singapore

    RECRUITING

    Singapore, 168583, Singapore

    Contact Email: •••••@•••••

  • National Cheng Kung University Hospital

    RECRUITING

    Tainan, Taiwan, 704, Taiwan

  • National Hospital Organization Hokkaido Cancer Center

    RECRUITING

    Sapporo, Hokkaido, 003-0804, Japan

  • National Taiwan University Hospital

    RECRUITING

    Taipei, Taiwan, 10002, Taiwan

  • National University Hospital

    RECRUITING

    Singapore, Singapore, 119074, Singapore

  • Niigata Cancer Center

    RECRUITING

    Niigata, Niigata, 951-8566, Japan

  • Oncology Associates of Oregon PC

    RECRUITING

    Eugene, Oregon, 97401, United States

  • Pan American Center for Oncology Trials

    RECRUITING

    San Juan, Puerto Rico, 00909, Puerto Rico

    Contact Email: •••••@•••••

  • Penn State Milton S. Hershey Medical Center

    RECRUITING

    Hershey, Pennsylvania, 17033, United States

  • Piedmont Healthcare, Inc

    RECRUITING

    Atlanta, Georgia, 30318, United States

  • Princess Margaret Hospital

    RECRUITING

    Lai Chi Kok, Hong Kong

  • Queen Mary Hospital

    RECRUITING

    Hong Kong, Hong Kong

    Contact Email: •••••@•••••

  • Radboudumc

    RECRUITING

    Nijmegen, 6525 GA, Netherlands

    Contact Email: •••••@•••••

  • Roswell Park Cancer Institute

    RECRUITING

    Buffalo, New York, 14263, United States

  • Royal Free Hospital

    RECRUITING

    London, W3 2QG, United Kingdom

  • Royal Marsden Hospital-London

    RECRUITING

    London, Greater London, SW3 6JJ, United Kingdom

  • Royal Marsden Hospital-Sutton

    RECRUITING

    Sutton, Surrey, SM2 5PT, United Kingdom

  • SCRI Oncology Partners - Tennessee

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Samsung Medical Center

    RECRUITING

    Seoul, 06351, South Korea

  • Sendai Kousei Hospital

    RECRUITING

    Sendai, Miyagi, 981-0914, Japan

  • Severance Hospital, Yonsei University Health System

    RECRUITING

    Seoul, 03722, South Korea

  • Shizuoka Cancer Center

    RECRUITING

    Nagaizumi-chō, Shizuoka, 411-8777, Japan

  • Sir Charles Gairdner Hospital

    RECRUITING

    Perth, Western Australia, 6009, Australia

  • St. George Private Hospital Clinical Trials Unit

    RECRUITING

    Kogarah, New South Wales, 2217, Australia

  • St. Vincent Frontier Cancer Center

    RECRUITING

    Billings, Montana, 59102, United States

  • Taipei Medical University Hospital

    RECRUITING

    Taipei, 110, Taiwan

  • Tallaght University Hospital

    RECRUITING

    Dublin, 24, Ireland

  • Taylor Cancer Research Center

    RECRUITING

    Maumee, Ohio, 43537, United States

  • Texas Oncology - Gulf Coast

    RECRUITING

    The Woodlands, Texas, 77380, United States

  • Texas Oncology - South Austin

    RECRUITING

    Austin, Texas, 78745, United States

  • Texas Oncology Dallas

    RECRUITING

    Dallas, Texas, 75251, United States

  • The Chinese University of Hong Kong

    RECRUITING

    Shatin, 00000, Hong Kong

  • The Christie NHS Foundation Trust

    RECRUITING

    Manchester, M20 4BX, United Kingdom

  • The Clatterbridge Cancer Centre

    RECRUITING

    Liverpool, Merseyside, L7 8YA, United Kingdom

  • The University of Kansas Cancer Center

    RECRUITING

    Westwood, Kansas, 66205, United States

  • Thoraxklinik Heidelberg gGmbH

    RECRUITING

    Baden, Wuerttemberg, 69469, Germany

  • Tohoku University Hospital

    RECRUITING

    Sendai, Miyagi, 980-8574, Japan

  • TriHealth Cancer & Blood Institute Research

    RECRUITING

    Cincinnati, Ohio, 45220, United States

  • UNC Lineberger Comprehensive Cancer Center at University of North Carolina

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

  • UZ Leuven-Campus Gasthuisberg

    RECRUITING

    Leuven, 3000, Belgium

  • Universitaetsklinikum Carl Gustav Carus TU Dresden

    RECRUITING

    Dresden, Saxony, 01307, Germany

  • Universitaetsklinikum Essen

    RECRUITING

    Essen, North Rhine-Westphalia, 45147, Germany

  • University Cancer and Blood Center

    RECRUITING

    Athens, Georgia, 30607, United States

    Contact Email: •••••@•••••

  • University Hospital Limerick

    RECRUITING

    Cork, Limerick, V94 F858, Ireland

  • University of Iowa Health Care Cancer Services Quad Cities

    RECRUITING

    Bettendorf, Iowa, 52722, United States

  • University of Iowa Health Care, Mission Cancer + Blood

    RECRUITING

    Waukee, Iowa, 50263, United States

  • University of Iowa Hospitals & Clinics

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • Universitätsspital Basel

    RECRUITING

    Basel, 4031, Switzerland

  • Utah Cancer Specialists

    RECRUITING

    Salt Lake City, Utah, 84106, United States

    Contact Email: •••••@•••••

  • Virginia Cancer Specialists

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Wakayama Medical University Hospital

    RECRUITING

    Wakayama, Wakayama, 641-8510, Japan

  • Washington University School of Medicine - Siteman Cancer Center

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Email: •••••@•••••

  • Winship Cancer Institute

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Yale University, Smillow Cancer Center

    RECRUITING

    New Haven, Connecticut, 06519, United States

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